{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:06:58Z","timestamp":1790845618471,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The oncologic and functional outcome of transoral laser microsurgery (TLM) for primary treatment of hypopharyngeal cancer was examined in a multimodal treatment concept.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred eleven patients with squamous cell carcinoma (SCC) of the hypopharynx (pT1\u20104a, pN0\u20102, M0) were treated by TLM +\/\u2212 neck dissection (88%) +\/\u2212 (chemo)radiotherapy ([C]RT; 51%). The majority of cases were advanced stages III and IVa (85%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year Kaplan\u2010Meier estimates for local control after TLM were pT category\u2010related 88.1%, 74.8%, 77.3%, and 61.8% for pT1\u20104a tumors. The 5\u2010year estimates of overall survival (OS), disease\u2010specific survival (DSS), and recurrence\u2010free survival (RFS) for early stages I and II were 68.2%, 96.7%, and 74.6%, respectively; for stage III they were 65.9%, 83.8%, and 56.4%, respectively; and the rates for stage IVa were 44.5%, 60.7%, and 50.3%, respectively. Overall, 95.7% of the patients maintained regular oral nutrition without feeding tube dependency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Primary TLM in multimodal concepts of treatment (+\/\u2212 neck dissection, +\/\u2212 [C]RT) offers favorable oncologic results as compared with other therapeutic regimes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24814","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T06:42:41Z","timestamp":1493966561000},"page":"1631-1638","source":"Crossref","is-referenced-by-count":44,"title":["Transoral laser microsurgery for treatment for hypopharyngeal cancer in 211 patients"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8368-0149","authenticated-orcid":false,"given":"Bernhard G.","family":"Weiss","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Medical Center G\u00f6ttingen G\u00f6ttingen 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