{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T03:15:22Z","timestamp":1761621322105,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lip cancer is one of the most curable primary head and neck malignancies, as the prominent location typically lends to an early diagnosis. The incidence of lip cancer varies by sex, ethnicity, and region, but is estimated to be up to 2.5\/100\u00a0000 in the United States (squamous cell carcinoma [SCC]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This article will review the current literature and National Comprehensive Cancer Network practice guidelines in the treatment of lip cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Resection of lip cancer with negative margins remains the mainstay of therapy. Positive nodal disease should be treated with neck dissection and adjuvant radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lip cancer remains highly curable when diagnosed at an early stage. A multidisciplinary approach is crucial to treating patients with advanced\u2010stage lip cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24817","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T05:22:52Z","timestamp":1496640172000},"page":"1505-1509","source":"Crossref","is-referenced-by-count":13,"title":["AHNS Series \u2013 Do you know your guidelines? Lip cancer"],"prefix":"10.1002","volume":"39","author":[{"given":"William","family":"Dougherty","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Virginia Health System Charlottesville Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-5077","authenticated-orcid":false,"given":"Babak","family":"Givi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery New York University Langone Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-2779","authenticated-orcid":false,"given":"Mark J.","family":"Jameson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Virginia Health System Charlottesville Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Education Committee of the American Head and Neck Society","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00109-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1622.2000.01827.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2009.12.022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.07.012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"issue":"10","key":"e_1_2_6_7_1","first-page":"1843","article-title":"Obliteration of fat planes by perineural spread of squamous cell carcinoma along the inferior alveolar nerve","volume":"15","author":"Matzko J","year":"1994","journal-title":"AJNR Am J Neuroradiol."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000055744"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200003000-00012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10079"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.09.020"},{"key":"e_1_2_6_12_1","unstructured":"BakerSR.Current management of cancer of the lip.Oncology (Williston Park). 1990;4(9):107\u2013120; discussion 122\u2010124.http:\/\/ovidsp.ovid.com\/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=2145016. 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