{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:46:10Z","timestamp":1793159170205,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Musikforlaeggerne Agnes og Knut M\u00f8rk's Foundation"},{"name":"Direkt\u00f8r Jacob Madsen & Hustru Olga Madsen's Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Using the thoroughly validated Thyroid\u2010Related Quality\u2010of\u2010Life Patient\u2010Reported Outcome (ThyPRO) questionnaire, the purpose of this study was to investigate changes in disease\u2010specific quality of life (QOL) after surgical treatment in patients with benign nontoxic multinodular goiters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with goiters scheduled for thyroid surgery (n = 106) and individuals from the general population (n = 739) were studied. The ThyPRO data before, 3 months, and 6 months after surgery were compared with normative scores from the general population using a linear mixed model and <jats:italic>t<\/jats:italic> tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before surgery, patients with goiters experienced poorer scores on all scales compared to the general population. After surgery, moderate to large improvements were seen in goiter symptoms, tiredness, anxiety, and overall QOL. After surgery, all scales returned to values equal to the general population. The degree of anxiety was, in fact, lower than in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thyroid surgery leads to significant benefit among patients with benign nontoxic goiters by restoring QOL equal to that in the general population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24886","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T10:50:02Z","timestamp":1504608602000},"page":"2232-2240","source":"Crossref","is-referenced-by-count":44,"title":["Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-8873","authenticated-orcid":false,"given":"Jesper Roed","family":"Sorensen","sequence":"first","affiliation":[{"name":"Department of ORL Head &amp; Neck Surgery Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torquil","family":"Watt","sequence":"additional","affiliation":[{"name":"Department of Medical Endocrinology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Cramon","sequence":"additional","affiliation":[{"name":"Department of Medical Endocrinology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle","family":"D\u00f8ssing","sequence":"additional","affiliation":[{"name":"Department of ORL Head &amp; Neck Surgery Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Heged\u00fcs","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Joop","family":"Bonnema","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Godballe","sequence":"additional","affiliation":[{"name":"Department of ORL Head &amp; Neck Surgery Odense University Hospital Odense Denmark"},{"name":"OPEN, Odense Patient data Explorative Network Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,4]]},"reference":[{"issue":"9","key":"e_1_2_6_2_1","first-page":"3071","article-title":"Major role of genes in the etiology of simple goiter in females: a population\u2010based twin study","volume":"84","author":"Brix TH","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2014.01.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90178-G"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811399556"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2012.96"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0069"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199811000-00005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2006.06.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2014.01.009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1030"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21091"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1806"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0917"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.1"},{"issue":"5","key":"e_1_2_6_17_1","first-page":"622","article-title":"American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules\u20132016 Update","volume":"22","author":"Gharib H","year":"2016","journal-title":"Endocr Pract."},{"issue":"6","key":"e_1_2_6_18_1","first-page":"1068","article-title":"Acute airway distress due to thyroid pathology","volume":"102","author":"Shaha A","year":"1987","journal-title":"Surgery."},{"issue":"10","key":"e_1_2_6_19_1","first-page":"3636","article-title":"The feasibility of high dose iodine 131 treatment as an alternative to surgery in patients with a very large goiter: effect on thyroid function and size and pulmonary function","volume":"84","author":"Bonnema SJ","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0822-7"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.05.005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198903001-00018"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1322"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-014-0798-1"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-013-0462-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0521"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.07.061"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-014-1221-7"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.08.001"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2133-3"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0433"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2584-z"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-009-9460-8"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-014-0126-z"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0209"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_6_38_1","volume-title":"Statistical power analyses for behavioral sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198903001-00015"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2014.03.002"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813487301"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2014.10.007"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(99)00045-3"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0708"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365211"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0370"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500439"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510030"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:45:54Z","timestamp":1695991554000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,4]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/hed.24886"],"URL":"https:\/\/doi.org\/10.1002\/hed.24886","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,4]]}}}