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The purpose of this study was to determine the correlation among ocular surface changes, xerostomia, and changes in the nasal mucosa associated with radioiodine therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients subjected to radioiodine therapy (group 1) or not subjected (group 2) were prospectively evaluated by examinations of the ocular surface and tear film, saliva production, and nasal endoscopy. Ocular and nasal symptoms and xerostomia were evaluated using questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Evaluation of the ocular surface did not indicate significant differences between the groups. Nasal endoscopy revealed higher mucosal pallor in group 1 and worsening of the endoscopic appearance. Worsening of ocular symptoms and nasal symptoms, xerostomia, and a significant decrease in salivary production was also observed in group 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subjective worsening of xerostomia, xerophthalmia, nasal symptoms, and changes in the nasal mucosa in group 1 was observed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24895","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T15:46:46Z","timestamp":1506354406000},"page":"2381-2396","source":"Crossref","is-referenced-by-count":12,"title":["Correlation among ocular surface disease, xerostomia, and nasal symptoms in patients with differentiated thyroid carcinoma subjected to radioiodine therapy: A prospective comparative study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0164-9816","authenticated-orcid":false,"given":"Fabricio Lopes","family":"da Fonseca","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Kazue","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Mazoti","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lica","family":"Arakawa\u2010Sugueno","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Mika","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Matayoshi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"issue":"3","key":"e_1_2_5_2_1","first-page":"714","article-title":"The results of various modalities of treatment of well differentiated thyroid carcinomas: a retrospective review of 1599 patients","volume":"75","author":"Samaan NA","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"e_1_2_5_3_1","first-page":"1452","article-title":"Radioiodine secretion in tears","volume":"39","author":"Bakheet SM","year":"1998","journal-title":"J Nucl Med"},{"issue":"2","key":"e_1_2_5_4_1","first-page":"120","article-title":"Iodine\u2010131 for therapy of thyroid diseases. 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