{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T13:57:51Z","timestamp":1782655071217,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The survival outcomes for surgery + postoperative radiotherapy (S+RT) or surgery + postoperative chemoradiation (S+CRT) was compared in patients having oral tongue cancers with intermediate\u2010risk pathological features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the National Cancer Database (NCDB), overall survival (OS) for S+RT or S+CRT was estimated using the Kaplan\u2010Meier methods and Cox proportional hazard models in the entire population (n = 2803) and in a propensity\u2010matched cohort (n = 1136).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 3\u2010year OS was 73.3% for S+CRT versus 66.7% for S+RT (<jats:italic>P<\/jats:italic> = .02). The S+CRT improved the 3\u2010year OS for patients with 2 or more involved metastatic lymph nodes (\u22652 MLNs; <jats:italic>P<\/jats:italic> = .01) but not for patients with &lt;2 MLNs (<jats:italic>P<\/jats:italic> = .73). Undergoing S+CRT improved the 3\u2010year OS for patients with pathologic T classification (pT) pT3\u2010pT4 disease (<jats:italic>P<\/jats:italic> = .01) but not for patients with pT1\u2010pT2 disease (<jats:italic>P<\/jats:italic> = .18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Undergoing S+CRT was associated with improved survival for patients with tongue cancers with \u22652 MLNs and\/or pT3\u2010pT4 suggesting that specific intermediate\u2010risk pathological features benefit from treatment intensification.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24932","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:43:12Z","timestamp":1506613392000},"page":"2537-2548","source":"Crossref","is-referenced-by-count":10,"title":["Survival outcomes for postoperative chemoradiation in intermediate\u2010risk oral tongue cancers"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4484-462X","authenticated-orcid":false,"given":"Michael T.","family":"Spiotto","sequence":"first","affiliation":[{"name":"Department of Radiation and Cellular Oncology University of Chicago Medical Center Chicago Illinois"},{"name":"Department of Radiation Oncology University of Illinois Hospital and Health Sciences System Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina D.","family":"Jefferson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Illinois Hospital and Health Sciences System Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Wenig","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Illinois Hospital and Health Sciences System Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Markiewicz","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Illinois Hospital and Health Sciences System Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph R.","family":"Weichselbaum","sequence":"additional","affiliation":[{"name":"Department of Radiation and Cellular Oncology University of Chicago Medical Center Chicago Illinois"},{"name":"Department of Radiation Oncology University of Illinois Hospital and Health Sciences System Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Koshy","sequence":"additional","affiliation":[{"name":"Department of Radiation and Cellular Oncology University of Chicago Medical Center Chicago Illinois"},{"name":"Department of Radiation Oncology University of Illinois Hospital and Health Sciences System Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.10.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.09.058"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.036"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00817-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032641"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032646"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23869"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20279"},{"issue":"2","key":"e_1_2_6_10_1","first-page":"785","article-title":"Risk factors associated with disease recurrence in patients with stage III\/IV squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy","volume":"36","author":"Noble AR","year":"2016","journal-title":"Anticancer Res."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23662"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.11.013"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24631"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2015.0102"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.05.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-013-0532-y"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086922"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2006.03.019"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3702-x"}],"container-title":["Head &amp; 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