{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:43:28Z","timestamp":1771026208004,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T00:00:00Z","timestamp":1506729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oropharyngeal squamous cell carcinoma (SCC) frequently presents with cervical metastasis. Roles of human papillomavirus (HPV) status, among other factors, on laterality are elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Cancer Database was reviewed for oropharyngeal SCC diagnosed from 2010\u20102014. Predictors of clinically evident contralateral or bilateral nodal disease were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15\u00a0517 patients with oropharyngeal SCC met criteria. The majority was HPV\u2010positive. Histologically poorly differentiated tumors were more frequent in the HPV\u2010positive group (55.7% vs 37.6%; <jats:italic>P<\/jats:italic> &lt; .001). By incidence, there was no statistical difference in contralateral or bilateral nodal disease between HPV\u2010positive and HPV\u2010negative patients (14.2% vs 14.5%, respectively; <jats:italic>P<\/jats:italic> = .769). On multivariable analysis, notable predictors of contralateral or bilateral nodal disease included HPV\u2010positivity (odds ratio [OR] 1.26; 99% confidence interval [CI] 1.10\u20101.44), base of tongue (BOT) location (OR 2.15; 99% CI 1.88\u20102.45), poorly differentiated tumor (OR 1.72; 99% CI 1.20\u20102.46), and T4 classification (OR 6.65; 99% CI 5.34\u20108.28).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with HPV\u2010associated oropharyngeal SCC have increased likelihood of contralateral or bilateral nodal disease. Tumor grade, tumor location, and tumor size are also independent predictors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24964","type":"journal-article","created":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T10:52:55Z","timestamp":1506768775000},"page":"338-348","source":"Crossref","is-referenced-by-count":29,"title":["Predictors of contralateral\u2010bilateral nodal disease in oropharyngeal cancer: A National Cancer Data Base Study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1696-8521","authenticated-orcid":false,"given":"Masanari G.","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina"},{"name":"Stony Brook University School of Medicine Stony Brook New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry A.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Medical University of South Carolina Charleston South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.141"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29402"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.6412"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.06.019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1007\/978-3-319-40618-3","volume-title":"AJCC Cancer Staging Manual","author":"Amin MB","year":"2017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23438"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26439"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.12.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.09.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000217543.40027.1d"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9747-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.10320"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21044"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq210"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.02.011"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21436"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000184791.68804.0b"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2013.47.3.203"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e3181ddd088"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310016893"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.709"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21129"},{"key":"e_1_2_7_27_1","first-page":"29","article-title":"Using data on tumor grade in cancer registries to enhance surveillance of oropharyngeal cancers in relation to the human papillomavirus epidemic","volume":"43","author":"Polednak AP","year":"2016","journal-title":"J Registry Manag."},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"44676","DOI":"10.18632\/oncotarget.9225","article-title":"Biomarker quantification by multiplexed quantum dot technology for predicting lymph node metastasis and prognosis in head and neck cancer","volume":"7","author":"Hu Z","year":"2016","journal-title":"Oncotarget."}],"container-title":["Head &amp; 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