{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:21:46Z","timestamp":1740104506890,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01 DE023414"],"award-info":[{"award-number":["R01 DE023414"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010638","name":"Huntsman Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010638","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010637","name":"Huntsman Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007747","name":"University of Utah","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010638","name":"Huntsman Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010638","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA42014"],"award-info":[{"award-number":["P30 CA42014"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The main purpose of the current study was to define the familial aggregation of oropharyngeal squamous cell carcinoma (SCC) and risk to relatives of patients with oropharyngeal SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study utilizing linked population\u2010based genealogy and state cancer registry databases between 1966 and 2012. Relative risks for oropharyngeal SCC and other malignancies among patients with oropharyngeal SCC and their relatives were estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant excess pairwise relatedness was observed for oropharyngeal SCC diagnosed before age 65 years. Significant excess risk for oropharyngeal SCC was observed for first\u2010degree relatives of patients. Relatives of oropharyngeal SCC patients also demonstrated elevated rates of multiple other malignancies, including both lung and cervical cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Relatives of patients with oropharyngeal SCC display elevated risks of oropharyngeal, lung, and cervical cancers among others, suggesting a possible shared genetic etiology involving tobacco\u2010related and human papillomavirus (HPV)\u2010related malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24971","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T15:06:40Z","timestamp":1507734400000},"page":"384-393","source":"Crossref","is-referenced-by-count":3,"title":["Familial clustering of oropharyngeal squamous cell carcinoma in the Utah population"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8899-2304","authenticated-orcid":false,"given":"Marcus M.","family":"Monroe","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah"},{"name":"Huntsman Cancer Institute Salt Lake City Utah"},{"name":"George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6903-2049","authenticated-orcid":false,"given":"Mia","family":"Hashibe","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute Salt Lake City Utah"},{"name":"Division of Public Health, Department of Family and Preventative Medicine University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quinn","family":"Orb","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremiah","family":"Alt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah"},{"name":"George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Buchmann","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah"},{"name":"Huntsman Cancer Institute Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah"},{"name":"Huntsman Cancer Institute Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A.","family":"Cannon\u2010Albright","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute Salt Lake City Utah"},{"name":"Division of Genetic Epidemiology, Department of Internal Medicine University of Utah School of Medicine Salt Lake City Utah"},{"name":"George E. 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