{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:05:03Z","timestamp":1791990303263,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are no existing high\u2010volume studies characterizing human papillomavirus (HPV)\u2010associated nasopharyngeal cancer (NPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Cancer Data Base (NCDB) was queried for NPC with known HPV (2004\u20102013). Logistic regression ascertained factors associated with HPV\u2010positivity. Kaplan\u2010Meier overall survival (OS) was evaluated between HPV\u2010positive and HPV\u2010negative cohorts; Cox proportional hazards modeling assessed factors associated with OS. Patients with nonmetastatic disease receiving definitive chemoradiotherapy underwent propensity\u2010matched OS analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether, 956 patients were analyzed (32% HPV\u2010positive and 68% HPV\u2010negative). Median follow\u2010up was 23 months (range 0\u201067 months). The patients with HPV\u2010positive disease were younger, less likely to be uninsured, lived in more educated areas, and presented with more advanced T (but not N\/overall) classification. Median OS for HPV\u2010positive and HPV\u2010negative groups were 50 and 43 months, respectively (<jats:italic>P<\/jats:italic>\u2009=\u2009.171). The HPV status did not independently predict for OS (<jats:italic>P<\/jats:italic>\u2009=\u2009.183). No OS differences were observed after propensity matching (<jats:italic>P<\/jats:italic>\u2009=\u2009.734).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In what we believe as the only large study of HPV\u2010associated NPC, HPV neither correlates with nor predicts survival in NPC. 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