{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:11Z","timestamp":1786977851055,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsinki University Central Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In the absence of unified treatment protocol, we evaluated the management and outcomes of submandibular gland cancers in an unselected patient series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included all patients with resected submandibular gland cancer treated at the Helsinki University Hospital from 2000 to 2010 with a 5\u2010year minimum follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010five patients with cancer represented 30% of submandibular gland neoplasms, and most were adenoid cystic carcinomas (ACCs; 56%). At presentation, 3 patients showed clinical signs of probable malignancy. Of 22 neck dissection specimens, 5 patients (20%) had metastases with an occult metastasis rate of 4%. Cancer recurred in 11 patients (44%), of which 7 (28%) were only at a distant site. The 5\u2010year disease\u2010specific survival (DSS) and overall survival (OS) rates were 76%, and disease\u2010free survival (DFS) was 68%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Most tumors were ACCs differing from the histological pattern of parotid gland cancers. Occult metastases were rare. The rarity of submandibular gland cancer, its variable histological pattern, and varying biological behavior warrant centralized management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.24981","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T10:02:52Z","timestamp":1509357772000},"page":"154-162","source":"Crossref","is-referenced-by-count":43,"title":["Submandibular gland cancer: Specific features and treatment considerations"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-5237","authenticated-orcid":false,"given":"Katri","family":"Aro","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University of Helsinki and Helsinki University Hospital Helsinki Finland"},{"name":"School of Dentistry University of California Los Angeles, Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Tarkkanen","sequence":"additional","affiliation":[{"name":"Department of Pathology, HUSLAB University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riste","family":"Saat","sequence":"additional","affiliation":[{"name":"Department of Radiology, HUS Medical Imaging Center University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kauko","family":"Saarilahti","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, HUS Cancer Center University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Atula","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Tumours of the salivary glands","author":"El\u2010Naggar AK","year":"2017"},{"key":"e_1_2_8_3_1","volume-title":"Tumours of the salivary glands","author":"Barnes L","year":"2005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.02.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24691"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23914"},{"key":"e_1_2_8_7_1","volume-title":"UICC TNM Classification of Malignant Tumours","author":"Sobin LH","year":"2009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2520"},{"key":"e_1_2_8_9_1","unstructured":"Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research.www.cancer.fi\/syoparekisteri\/en\/statistics\/cancer-statistics\/koko-maa. 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