{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:46:05Z","timestamp":1790304365749,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:00:00Z","timestamp":1517529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We report on a patient with human immunodeficiency virus (HIV)\u2010positive disease with a primary orbital melanoma treated with surgery and adjuvant radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 53\u2010year\u2010old woman with HIV\u2010positive disease presented with left\u2010sided progressive ipsilateral vision loss and proptosis. An MRI scan revealed a mass\u2010enhancing lesion measuring 2.1 \u00d7 2.6 \u00d7 2.5 cm abutting the optic nerve. The patient underwent left orbital exenteration with temporalis flap reconstruction, pathology revealing malignant melanoma, stage T1N0M0. Posterior margins were positive and lymphovascular invasion was present; therefore, the patient received adjuvant radiation to a total dose of 70 Gy in 35 fractions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient remains with no evidence of disease (NED) at a follow\u2010up time of 3.5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgery remains the mainstay of treatment in patients with primary orbital melanomas, and adjuvant radiotherapy should be considered for those with positive margins or other risk factors for recurrence. We present a patient with significant risk factors with NED at 3.5\u2010year follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24983","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T17:12:41Z","timestamp":1517591561000},"source":"Crossref","is-referenced-by-count":10,"title":["Primary orbital melanoma treated with orbital exenteration and postoperative radiotherapy: A case report and review of the literature"],"prefix":"10.1002","volume":"40","author":[{"given":"Christopher P.","family":"Haskins","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sommer","family":"Nurkic","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristianna M.","family":"Fredenburg","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Florida College of Medicine Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Dziegielewski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Florida College of Medicine Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-2810","authenticated-orcid":false,"given":"William M.","family":"Mendenhall","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30585-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-199509000-00003"},{"key":"e_1_2_6_4_1","first-page":"2051","volume-title":"Principles and Practice of Ophthalmology","author":"Netland PA","year":"1994"},{"key":"e_1_2_6_5_1","volume-title":"The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the future of TNM","author":"Edge SB","year":"2011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2013.33376"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040031296011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19911215)68:12<2579::AID-CNCR2820681209>3.0.CO;2-G"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/01.IOP.0000075797.11247.F6","article-title":"Orbital malignant melanoma: the 2002 Sean B Murphy lecture","volume":"19","author":"Shields JA","year":"2003","journal-title":"Ophthal Plast Reconstr Surg."},{"issue":"75","key":"e_1_2_6_10_1","first-page":"1","article-title":"Malignant Melanomas of the uvea in Denmark 1943\u20101952. A clinical, histopathological, and prognostic study","volume":"43","author":"Jensen OA","year":"1963","journal-title":"Acta Ophthalmol (Copenh)."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-911X(200008)35:2<142::AID-MPO14>3.0.CO;2-N"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.1.118"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.302"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.24983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.24983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T20:24:01Z","timestamp":1695759841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.24983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,2]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/hed.24983"],"URL":"https:\/\/doi.org\/10.1002\/hed.24983","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,2]]}}}