{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T13:50:52Z","timestamp":1777125052356,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Carcinoma showing thymus\u2010like elements (CASTLE) is a rare tumor that normally affects the thyroid gland and was thought to arise from either the remnants of the branchial pouch or the ectopic cervical thymic tissue. These tumors show strong immunopositivity for CD5, P63, and CD117. Most CASTLE of the thyroid gland is treated with surgery with or without adjuvant radiotherapy or chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A 55\u2010year\u2010old woman presented with a slow\u2010growing right parotid mass. A right total parotidectomy and ipsilateral selective neck dissection were performed and the diagnosis of CASTLE was made after confirmation with an immunohistochemistry test. She received radiotherapy postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Genetic sequencing showed alterations in the <jats:italic>PPARG<\/jats:italic>, <jats:italic>BRCA2<\/jats:italic>, and <jats:italic>NOTCH1<\/jats:italic> genes. She remained disease free for &gt;1 year after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We believe that this is the first reported case of CASTLE in the parotid gland. Clinicians should be aware of this rare entity and consider this differential diagnosis after ruling out other common parotid lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.24985","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T14:46:47Z","timestamp":1510238807000},"source":"Crossref","is-referenced-by-count":24,"title":["CASTLE tumor of the parotid: First documented case, literature review, and genetic analysis of the cancer"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7780-2616","authenticated-orcid":false,"given":"Eugene Hung Chih","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University Hospital of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Tetter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University Hospital of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandar","family":"Tzankov","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics and Pathology University Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University Hospital of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01656263"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90083-2"},{"key":"e_1_2_4_4_1","first-page":"96","volume-title":"Pathology and Genetics of Tumours of Endocrine Organs","author":"Cheuk W CJ","year":"2010"},{"key":"e_1_2_4_5_1","unstructured":"Thermo Fisher Scientific Waltham MA.The Oncomine\u2122 Comprehensive Assay. 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