{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:43Z","timestamp":1786977943310,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T00:00:00Z","timestamp":1510358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health and Labor Sciences Research Grant for Clinical Cancer Research","award":["H22-017"],"award-info":[{"award-number":["H22-017"]}]},{"name":"Health and Labor Sciences Research Grant for Clinical Cancer Research","award":["H26-141"],"award-info":[{"award-number":["H26-141"]}]},{"name":"National Cancer Center Research and Development Fund","award":["23-A-16"],"award-info":[{"award-number":["23-A-16"]}]},{"name":"National Cancer Center Research and Development Fund","award":["23-A-21"],"award-info":[{"award-number":["23-A-21"]}]},{"name":"National Cancer Center Research and Development Fund","award":["26-A-4"],"award-info":[{"award-number":["26-A-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We are currently undertaking a multi\u2010institutional prospective trial of the superselective intra\u2010arterial infusion of high\u2010dose cisplatin with concomitant radiotherapy for patients with T4aN0M0 or T4bN0M0 locally advanced maxillary sinus squamous cell carcinomas (SCC). We herein report the results of the dose\u2010finding phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The dose\u2010finding phase sought to evaluate the incidence of dose\u2010limiting toxicities and determine the recommended number of cycles of the intra\u2010arterial infusion of cisplatin. In this phase, 100\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      of cisplatin was administered intra\u2010arterially weekly for 7 weeks with concomitant radiotherapy (70 Gy).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 18 patients received a full dose of radiotherapy. The number of cycles of cisplatin was 7 in 13 patients and 6 in 5 patients. The dose\u2010limiting toxicities were observed in 5 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results indicated that this therapy is safe and well\u2010tolerated at 7 cycles of cisplatin, which was determined to be the recommended number of cycles for locally advanced maxillary sinus SCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.25001","type":"journal-article","created":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T08:42:51Z","timestamp":1510389771000},"page":"475-484","source":"Crossref","is-referenced-by-count":22,"title":["Dose\u2010finding and efficacy confirmation trial of the superselective intra\u2010arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (Japan Clinical Oncology Group 1212): Dose\u2010finding phase"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-0646","authenticated-orcid":false,"given":"Akihiro","family":"Homma","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikiya","family":"Onimaru","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery, Miyagi Cancer Center Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Shinomiya","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Sakashita","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7461-1352","authenticated-orcid":false,"given":"Kiyoto","family":"Shiga","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Iwate Medical University School of Medicine Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Aichi Cancer Center Hospital Nagoya 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