{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:08:17Z","timestamp":1791972497545,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grant by the Korea government","award":["NRF-2015R1D1A1A02062345"],"award-info":[{"award-number":["NRF-2015R1D1A1A02062345"]}]},{"name":"National Research Foundation of Korea (NRF) grant by the Korea government","award":["NRF-2017M3A9E8033206"],"award-info":[{"award-number":["NRF-2017M3A9E8033206"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to investigate the effects of tonsil\u2010derived mesenchymal stem cells (MSCs) on osteoradionecrosis (ORN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We generated a mandibular ORN rat model using a combination of 20\u2010Gy single\u2010dose irradiation and tooth extraction. Study groups were negative control (tooth extraction only), ORN group (irradiation, tooth extraction), Matrigel\u20101 group (Matrigel; BD Biosciences, San Jose, CA; irradiation, Matrigel application immediately after tooth extraction), tonsil\u2010derived MSC\u20101 group (irradiation, tonsil\u2010derived MSC application immediately after tooth extraction), Matrigel\u20104 group (irradiation, Matrigel application 4 weeks after tooth extraction), and tonsil\u2010derived MSC\u20104 group (irradiation, tonsil\u2010derived MSC application 4 weeks after tooth extraction).<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Bone mineral density was significantly lower in the ORN group than in the negative control group. The tonsil\u2010derived MSC\u20101 group showed significantly higher bone mineral density than did the ORN and tonsil\u2010derived MSC\u20104 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single 20\u2010Gy dose of irradiation combined with tooth extraction successfully generated ORN in the rat model. The tonsil\u2010derived MSCs can be effective for bone regeneration in ORN, particularly when applied immediately after dentoalveolar trauma or surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25004","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T14:12:39Z","timestamp":1510755159000},"page":"526-535","source":"Crossref","is-referenced-by-count":26,"title":["Preventive effects of tonsil\u2010derived mesenchymal stem cells on osteoradionecrosis in a rat model"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5968-2507","authenticated-orcid":false,"given":"Hae Sang","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery, Chuncheon Sacred Heart Hospital Hallym University, School of Medicine Chuncheon Republic of Korea"},{"name":"Nano\u2010Bio Regenerative Medical Institute Hallym University, School of Medicine Chuncheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, School of Medicine Ewha Womans University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Ewha Womans University Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Medicine Ewha Womans University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Yeon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, School of Medicine EwhaWomans University Seoul Republic of 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