{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T03:55:00Z","timestamp":1754020500252,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pathways to Discovery grant from the University of California San Francisco School of Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment for squamous cell carcinoma (SCC) of unknown primary consists of radiotherapy (RT) +\/\u2010 chemotherapy or neck dissection +\/\u2010 adjuvant RT\/chemoradiotherapy (CRT). We compared these strategies and identified prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 1993 to 2015, 75 patients with SCC of unknown primary had RT\u2010based or surgery\u2010based treatment. Primary endpoints were overall survival (OS) and disease\u2010free survival (DFS). Event\u2010time distributions were estimated using the Kaplan\u2010Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five\u2010year OS and DFS for RT\u2010based and surgery\u2010based treatments were similar (OS 73% vs 68%, respectively; DFS 65% vs 64%, respectively). Among 38 patients with p16 data, 76% were p16 positive and showed improved 5\u2010year DFS (90% vs 33%; <jats:italic>P<\/jats:italic> = .001) and OS (96% vs 33%; <jats:italic>P<\/jats:italic> &lt; .001). Smoking history \u226410 pack\u2010years conferred better 5\u2010year DFS (88% vs 49%; <jats:italic>P<\/jats:italic> &lt; .001) and OS (91% vs 59%; <jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RT\u2010based and surgery\u2010based treatments produced similar outcomes. Patients with p16\u2010positive disease with \u226410 pack\u2010years of smoking history and limited nodal stage constitute a \u201clow\u2010risk\u201d group in SCC of unknown primary similar to that in oropharyngeal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25028","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T09:52:44Z","timestamp":1512553964000},"page":"904-916","source":"Crossref","is-referenced-by-count":14,"title":["Squamous cell carcinoma of unknown primary of the head and neck: Favorable prognostic factors comparable to those in oropharyngeal cancer"],"prefix":"10.1002","volume":"40","author":[{"given":"Margaret J.","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of California San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemieke","family":"van Zante","sequence":"additional","affiliation":[{"name":"Department of Pathology 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