{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:11:02Z","timestamp":1783519862685,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this research was to investigate the association between alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) polymorphisms and hypopharyngeal squamous cell carcinoma (SCC) survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We genotyped ADH1B (rs1229984) and ALDH2 (rs671) single nucleotide polymorphisms (SNPs) in 85 Japanese male patients with hypopharyngeal SCC. The independent prognostic values of ADH1B\u2010ALDH2 genotypes were analyzed by univariate and multivariate proportional hazard Cox regression, taking well\u2010known clinical risk factors into account.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Heavy drinkers with ALDH2*2 allele resulted in significantly worse overall survival (OS; <jats:italic>P<\/jats:italic> = .028) and disease\u2010free survival (DFS; <jats:italic>P<\/jats:italic> = .029) compared with other patients. Heavy drinkers with ALDH2*2 allele remained statistically significant in multivariate analysis for OS and DFS, indicating independent poor prognostic factor (hazard ratio [HR] 2.251; 95% confidence interval [CI] 1.018\u20104.975 and HR 2.261; 95% CI 1.021\u20105.006, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that heavy drinkers with the ALDH2*2 allele are associated with poor outcome in hypopharyngeal SCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25050","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T12:22:42Z","timestamp":1514550162000},"page":"770-777","source":"Crossref","is-referenced-by-count":28,"title":["Impact of alcohol dehydrogenase\u2010aldehyde dehydrogenase polymorphism on clinical outcome in patients with hypopharyngeal cancer"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3896-5807","authenticated-orcid":false,"given":"Mehmet Ozgur","family":"Avin\u00e7sal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Kobe University Graduate School of Medicine Kobe Japan"},{"name":"Department of Diagnostic Pathology Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7545","authenticated-orcid":false,"given":"Hirotaka","family":"Shinomiya","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Teshima","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Kobe University Graduate School of Medicine Kobe 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