{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:41:33Z","timestamp":1792122093955,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:00:00Z","timestamp":1515715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Internal departmental funding was utilized without commercial sponsorship or support"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study presents oncologic outcomes after transoral robotic surgery (TORS) \u00b1 adjuvant therapy for oropharyngeal squamous cell carcinoma (SCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred fourteen patients undergoing TORS \u00b1 adjuvant therapy for oropharyngeal SCC from May 1, 2007, to May 31, 2015, are analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up was 3.3 years (interquartile range [IQR] 1.8\u20105.3 years; range 1 day to 9.3 years). Estimated locoregional recurrence\u2010free survival, distant metastasis\u2010free survival (DMFS), overall survival (OS), and cancer\u2010specific survival (CSS) rates (95% confidence interval [CI] number still at risk) at 5 years after surgery were 92% (88\u201095; 92), 90% (86\u201094; 92), 86% (82\u201092; 98), and 94% (91\u201097; 98), respectively. Negative margins were achieved in 98% of cases. The adult comorbidity evaluation (ACE)\u201027 comorbidity index, human papillomavirus (HPV) status, pathologic N classification, and number of attempts to clear margins were associated with death due to cancer (<jats:italic>P<\/jats:italic> = .003, <jats:italic>P<\/jats:italic> = .002, <jats:italic>P<\/jats:italic> = .030, and <jats:italic>P<\/jats:italic> = .002, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The need to take \u22652 margins to achieve resection portends an increased risk of locoregional recurrence and death due to disease in oropharyngeal SCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25055","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T10:26:42Z","timestamp":1515752802000},"page":"747-755","source":"Crossref","is-referenced-by-count":113,"title":["Transoral robotic surgery for oropharyngeal carcinoma: Surgical margins and oncologic outcomes"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1103-6212","authenticated-orcid":false,"given":"Eric J.","family":"Moore","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Mayo Clinic School of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0513-4203","authenticated-orcid":false,"given":"Kathryn M.","family":"Van Abel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Mayo Clinic School of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Mayo Clinic School of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Lohse","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic School of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry D.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Mayo Clinic School of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Washington University St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliot J.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Mayo Clinic School of Medicine Rochester 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