{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T06:31:36Z","timestamp":1766557896181,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Team Science Grant"},{"name":"Debi and Shelly Friedman"},{"name":"Philanthropic Gift"},{"name":"The University of Chicago Comprehensive Cancer Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral cavity squamous cell carcinoma (SCC) arising in nonsmokers and nondrinkers remains poorly characterized. We hypothesized that these patients had prior exposure to metallic dental hardware.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized a questionnaire querying the lifetime oral health status of 54 patients. Demographics and extensive oral health history were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of patients (74%) had prior exposure to metallic dental hardware. The younger population with almost exclusively oral tongue cancer had a high prevalence of metallic orthodontic braces (40%) within 15 years before diagnosis. In the 51+ year age group, 82% had crowns, dental implants, and\/or dentures with metallic elements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exposure to metallic dental hardware has increased in the past few decades given the rise of orthodontic braces and older adults retaining more teeth. Although this study does not prove a causal relationship between oral cavity SCC and dental hardware, this is a step toward identifying and investigating their role.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25059","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T16:50:20Z","timestamp":1516639820000},"page":"784-792","source":"Crossref","is-referenced-by-count":22,"title":["Role of dental hardware in oral cavity squamous cell carcinoma in the low\u2010risk nonsmoker nondrinker population"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1558-9693","authenticated-orcid":false,"given":"Jessica A.","family":"Yesensky","sequence":"first","affiliation":[{"name":"Department of Surgery The University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rifat","family":"Hasina","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Chicago Chicago 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