{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:32:35Z","timestamp":1785281555846,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three patients with ONB were included from the French Rare Head and Neck Cancer Expert Network (REFCOR) database: 16T1, 8T2, 19T3, and 10T4. All cases were treated endoscopically with skull base removal and repair in 26 cases (49%) and without external craniotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall survival (OS) and disease\u2010free survival (DFS) rates at 5 years were 87% and 71%, respectively, with mean follow\u2010up of 45.4\u2009\u00b1\u200926.5 months. The complication rate was 18.8% with 4 cases of meningitis. Pathological analysis showed positive margins in 26.8%, notably on the dura\u2010mater and periorbita, without impairment of OS or DFS. Forty\u2010eight patients received adjuvant radiotherapy on T\u2009\u00b1\u2009N. Ten patients had a recurrence (18.9%). Six patients died of their disease. Prophylactic neck irradiation seemed to reduce the recurrence rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exclusively endoscopic treatment proved efficient and reliable in a large controlled series.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25064","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T16:50:32Z","timestamp":1516639832000},"page":"1000-1007","source":"Crossref","is-referenced-by-count":31,"title":["Multicenter assessment of exclusive endoscopic endonasal approach for the treatment of 53 olfactory neuroblastomas"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0113-6121","authenticated-orcid":false,"given":"Ludovic","family":"de Gabory","sequence":"first","affiliation":[{"name":"Otorhinolaryngology, Head and Neck Surgery Department University Hospital Pellegrin Bordeaux 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