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However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We calculate the survival rate and prognostic factors using a Kaplan\u2010Meier analysis and Cox proportional hazards regression model. Copy number variations were analyzed using a single\u2010nucleotide polymorphism (SNP) array.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year disease\u2010free and cancer\u2010free survival rates of patients with oral verrucous hyperplasia were approximately 40% and 70%, respectively. Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions were risk factors for malignant transformation, whereas dysplasia did not affect outcomes. The gene amplification of <jats:italic>CTTN, FOLR3, ORAOV1, PPFIA1<\/jats:italic>, and <jats:italic>RNF121<\/jats:italic> were associated with the poor prognosis of oral verrucous hyperplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions are high\u2010risk factors of patients with oral verrucous hyperplasia. The 5\u2010copy number variation\u2010associated genes could be used for early diagnosis and predicting the prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25076","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T22:15:09Z","timestamp":1517264109000},"page":"1046-1056","source":"Crossref","is-referenced-by-count":18,"title":["Risk analysis of malignant potential of oral verrucous hyperplasia: A follow\u2010up study of 269 patients and copy number variation analysis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-9144","authenticated-orcid":false,"given":"Ming\u2010Heng","family":"Wu","sequence":"first","affiliation":[{"name":"Graduate Institute of Translational Medicine, College of Medical Science and Technology Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Dung","family":"Luo","sequence":"additional","affiliation":[{"name":"Bioinformatics Core Laboratory, Molecular Medicine Research Center Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Chang","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Translational Medicine, College of Medical Science and Technology Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu\u2010Hao","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Informatics, College of Medical Science and Technology Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Lun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Translational Medicine, College of Medical Science and Technology Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuen\u2010Haur","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyun\u2010Yeu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Chi\u2010Mei Medical Center Liouying Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Wu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Sin\u2010Lau Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Ta","family":"Chiou","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery An\u2010Nan Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Hua","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Chang\u2010Chung Memorial Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Fan","family":"Chiang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Translational Medicine, College of Medical Science and Technology Taipei Medical University Taipei Taiwan"},{"name":"Department of Oral and Maxillofacial Surgery, Chi\u2010Mei Medical Center Liouying Taiwan"},{"name":"School of Dentistry National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Taiwan Cancer Registry annual report.Health Promotion Administration Ministry of Health and Welfare Taiwan;2014.http:\/\/www.hpa.gov.tw\/EngPages\/Index.aspx. 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