{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:17:27Z","timestamp":1767896247092,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to present the outcomes of oropharyngeal cancers treated with intensity\u2010modulated radiotherapy (IMRT) especially the differences between tonsillar and base of tongue (BOT) primaries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of 124 patients with biopsy proven squamous cell carcinomas of the oropharynx, treated with IMRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human papillomavirus (HPV) association correlated with improvement in survivals in both tonsillar and BOT primaries. At the 2\u2010year median follow\u2010up, the cumulative incidences of locoregional recurrences were 8% in both the tonsil and BOT groups (<jats:italic>P<\/jats:italic>\u2009=\u2009.76) but the distant metastases were 8% in the tonsil group versus 26% in the BOT group (<jats:italic>P<\/jats:italic>\u2009=\u2009.009). Thirty percent of tonsil primaries has \u2265N2c neck disease as compared to 54% of BOT. Incidence of distant metastases increases with advanced nodal classification, especially &gt;N2c.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Even though the locoregional controls are excellent with IMRT and chemotherapy, these patients continue to fail distantly, particularly significant for the BOT group and for nodal stage &gt;N2c.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25077","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T22:39:06Z","timestamp":1517438346000},"page":"1034-1039","source":"Crossref","is-referenced-by-count":7,"title":["Outcomes utilizing intensity\u2010modulated radiotherapy in oropharyngeal cancers: Tonsils versus base of tongue"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6015-3207","authenticated-orcid":false,"given":"Madhava R.","family":"Kanakamedala","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Mississippi Medical Center Jackson Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shankar P. G.","family":"Giri","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Mississippi Medical Center Jackson Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Mississippi Medical Center Jackson Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldrin","family":"Bhanat","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Mississippi Medical Center Jackson Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivasan","family":"Vijayakumar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Mississippi Medical Center Jackson Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90167-T"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032646"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032641"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20279"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.021"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12432"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.006"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.08.004"},{"issue":"10","key":"e_1_2_5_11_1","first-page":"915","article-title":"Head and neck cancer: changing epidemiology and public health implications","volume":"24","author":"Kim L","year":"2010","journal-title":"Oncology (Williston Park)"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv344"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2016.07.005"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01690-X"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00663-5"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14361-9"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69121-6"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70290-4"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28372"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12674"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23578"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.10.041"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.017"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20694"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23245"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20012"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.10.035"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.09.005"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.10.016"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_5_31_1","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2012.30.15_suppl.5566","article-title":"ECOG 1308: A phase II trial of induction chemotherapy followed by cetuximab with low dose versus standard dose IMRT in patients with HPV\u2010associated resectable squamous cell carcinoma of the oropharynx (OP)","volume":"30","author":"Marur S","year":"2012","journal-title":"J Clin Oncol"},{"key":"e_1_2_5_32_1","unstructured":"NRG Oncology.Reduced\u2010dose intensity\u2010modulated radiation therapy with or without cisplatin in treating patients with advanced oropharyngeal cancer.www.clinicaltrials.gov\/ct2\/show\/NCT02254278. Accessed January 3 2017."}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.25077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:59:27Z","timestamp":1695574767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,31]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/hed.25077"],"URL":"https:\/\/doi.org\/10.1002\/hed.25077","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,31]]}}}