{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:27:39Z","timestamp":1792682859574,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effects of perioperative hyperglycemia on complications and outcomes in microvascular reconstruction have not been reported in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort of 203 patients undergoing microvascular reconstruction was generated. Perioperative glucose levels and clinical factors were tested for associations with complications using simple and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hyperglycemia (blood glucose\u2009\u2265\u2009180\u2009mg\/dL) occurred in 91 patients (44.8%) perioperatively, and was associated with increased rates of surgical complications, medical complications, surgical site infections, fistulas, and wound dehiscence. On univariate analysis, a more strict definition of hyperglycemia (blood glucose\u2009\u2265\u2009165\u2009mg\/dL) was significantly associated with greater rates of venous thrombosis, although this lost statistical significance on multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Perioperative hyperglycemia occurs commonly in patients undergoing microvascular reconstruction and is associated with higher rates of complications, independent of a preexisting diagnosis of diabetes mellitus. Further research is needed to define the ideal glycemic target in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25097","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T04:22:43Z","timestamp":1519964563000},"page":"1196-1206","source":"Crossref","is-referenced-by-count":12,"title":["Impact of perioperative hyperglycemia in patients undergoing microvascular reconstruction"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-5338","authenticated-orcid":false,"given":"Craig A.","family":"Bollig","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Missouri School of Medicine Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire S.","family":"Spradling","sequence":"additional","affiliation":[{"name":"University of Missouri School of Medicine Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Dooley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Missouri School of Medicine Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabitha L.","family":"Galloway","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Missouri School of Medicine Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B.","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Missouri School of Medicine Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.08.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2005.11.013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2009.05.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24097"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22454"},{"issue":"8","key":"e_1_2_7_7_1","first-page":"607","article-title":"Risk factors for wound infection after cholecystectomy","volume":"103","author":"Chuang SC","year":"2004","journal-title":"J Formos Med Assoc"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.5.1518"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31827b6bbc"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.08.006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000215887.59922.36"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0304"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000688"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.11.015"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-016-0721-y"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/501620"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP09102.RA"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815607852"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04997-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011300"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.05.006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182a53981"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31818990d1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199701000-00024"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.4065\/80.7.862"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-07-0447"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e328361a942"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02972-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.14.1681"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182a501e3"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-016-0719-5"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000121747.71054.79"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)00014-4"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.2981"}],"container-title":["Head &amp; 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