{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:01:47Z","timestamp":1791820907564,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA219534"],"award-info":[{"award-number":["R01 CA219534"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although perineural invasion (PNI) is recognized as an adverse prognostic factor in oral tongue squamous cell carcinoma (SCC), the patterns of failure are poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with oral tongue SCC who received primary surgical treatment were identified. Specimens were reviewed by head and neck pathologists. Disease\u2010specific survival (DSS) and locoregional recurrence\u2010free survival (LRFS), regional recurrence\u2010free survival (RRFS), and distant recurrence\u2010free survival (DRFS) were calculated. The PNI and PNI characteristics were analyzed as predictors of outcome. The utility of grading the extent of PNI was assessed by quantifying the number of PNI foci per slide reviewed, nerve caliber, and percent circumference involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with PNI had a decreased DSS; however, PNI was not predictive of LRFS or RRFS. Patients with PNI were more likely to develop a distant recurrence and 19.40 (confidence interval [CI] 6.70\u201056.14;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) times more likely to develop a distant recurrence if PNI foci density was &gt;1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The presence of PNI in oral tongue SCC predicts worse DSS, with distant recurrence as the most common pattern of failure. High PNI foci density is associated with worse DRFS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.25110","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T11:09:07Z","timestamp":1520593747000},"page":"1287-1295","source":"Crossref","is-referenced-by-count":81,"title":["Patterns of recurrence in oral tongue cancer with perineural invasion"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-906X","authenticated-orcid":false,"given":"Jennifer R.","family":"Cracchiolo","sequence":"first","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn C.","family":"Migliacci","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Katabi","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal G.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A.","family":"Ghossein","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6259-7314","authenticated-orcid":false,"given":"Richard J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"The Surveillance Epidemiology and End Results (SEER) Program.Cancer Stat Facts: Oral Cavity and Pharynx Cancer.https:\/\/seer.cancer.gov\/statfacts\/html\/oralcav.html. 2013. Accessed May 1 2017."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.6.637"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813506867"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2182-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23821"},{"key":"e_1_2_5_7_1","unstructured":"National Comprehensive Cancer Network (NCCN).NCCN Guidelines Insights: Head and Neck Cancers Version 2.2017.http:\/\/www.jnccn.org\/content\/15\/6\/761.abstract. Accessed May 1 2017."},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032641"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1548"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24458"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26229"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199810)20:7<588::AID-HED2>3.0.CO;2-F"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199410000-00003"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199503000-00005"},{"key":"e_1_2_5_15_1","first-page":"3153","article-title":"Perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with PT1\u20103N0M0 esophageal squamous cell carcinoma","volume":"8","author":"Sheng L","year":"2015","journal-title":"Onco Targets Ther"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5637-x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2015.379"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000214"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10400"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5356-3"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003770"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.10.011"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24396"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948509400420"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0722-9"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.25110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:20:47Z","timestamp":1695486047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/hed.25110"],"URL":"https:\/\/doi.org\/10.1002\/hed.25110","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,9]]}}}