{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:58:37Z","timestamp":1773662317979,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thyroid disease occurs more frequently in patients with hyperparathyroidism than the general population and hinders parathyroid localization. Identifying thyroid pathology before operating improves management and avoids the risks of reoperation in the neck. This review assesses imaging studies in patients with hyperparathyroidism and thyroid pathology to identify the ideal imaging methodology for patients with multigland disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic review of original articles reporting sensitivity or positive predictive value (PPV) for one or more imaging modalities in patients with hyperparathyroidism and thyroid disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight studies, 13 prospective and 15 retrospective, met inclusion criteria. Nine modalities were evaluated, including: cervical ultrasound (n\u2009=\u200918), dual\u2010phase <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi (n\u2009=\u200914), subtraction scintigraphy (n\u2009=\u200911), combined ultrasound and scintigraphy (n\u2009=\u20098), single photon emission CT (SPECT; n\u2009=\u20095), SPECT\u2010CT (n\u2009=\u20094), contrast\u2010enhanced ultrasound (n\u2009=\u20091), CT (n\u2009=\u20091), and MRI (n\u2009=\u20091).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combined ultrasound and scintigraphy is the most sensitive study to localize parathyroid adenomas in patients with hyperparathyroidism and thyroid disease, followed by hybrid SPECT\u2010CT and SPECT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25111","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T19:48:28Z","timestamp":1519242508000},"page":"1577-1587","source":"Crossref","is-referenced-by-count":11,"title":["Preoperative imaging for parathyroid localization in patients with concurrent thyroid disease: A systematic review"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7029-3468","authenticated-orcid":false,"given":"Ethan","family":"Frank","sequence":"first","affiliation":[{"name":"Loma Linda University School of Medicine Loma Linda California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Ale\u2010Salvo","sequence":"additional","affiliation":[{"name":"Loma Linda University School of Medicine Loma Linda California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Loma Linda University Medical Center Loma Linda California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Loma Linda University Medical Center Loma Linda California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Alfred","family":"Simental","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Loma Linda University Medical Center Loma Linda California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared C.","family":"Inman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Loma Linda University Medical Center Loma Linda California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.11.1.49"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.01.001"},{"issue":"10","key":"e_1_2_6_4_1","first-page":"295","article-title":"Primary hyperparathyroidism and papillary adenocarcinoma of the thyroid; report of four cases","volume":"31","author":"Ogburn PL","year":"1956","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000203411.53666.AD"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0100419"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"42","article-title":"Is primary hyperparathyroidism a risk factor for papillary thyroid cancer? 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