{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:12:40Z","timestamp":1790482360641,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T00:00:00Z","timestamp":1520640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The purpose of this study was to assess changes resulting from the American Joint Committee on Cancer (AJCC) eighth edition for cutaneous squamous cell carcinoma (SCC) and evaluate pertinent excluded factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 101 patients receiving surgery and postoperative radiation, recurrence and survival were estimated by cumulative incidence and Kaplan\u2010Meier method. Time\u2010to\u2010event analysis was performed using Cox proportional hazards and Fine\u2010Gray competing risks regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 2\u2010year locoregional recurrence, overall survival (OS), and cause\u2010specific mortality rates were 25%, 72%, and 13%, respectively. The AJCC eighth edition upstaged T classification in 50% of patients and overall stage in 39%. In multivariate analysis, immunosuppression and in\u2010transit metastasis were associated with locoregional recurrence. Older age and in\u2010transit metastasis were associated with worse OS. In univariate analysis (limited by number of events), cause\u2010specific mortality was associated with positive margin, in\u2010transit metastasis, and the seventh edition dichotomized T classification and overall stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In\u2010transit metastasis was significantly associated with locoregional recurrence, OS, and cause\u2010specific mortality. Efforts should be made to define in\u2010transit metastasis in the staging system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.25114","type":"journal-article","created":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T00:02:45Z","timestamp":1520640165000},"page":"1406-1414","source":"Crossref","is-referenced-by-count":29,"title":["Major prognostic factors for recurrence and survival independent of the American Joint Committee on Cancer eighth edition staging system in patients with cutaneous squamous cell carcinoma treated with multimodality therapy"],"prefix":"10.1002","volume":"40","author":[{"given":"Melody J.","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann A.","family":"Lazar","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam A.","family":"Garsa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah T.","family":"Arron","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan H.","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain P.","family":"Algazi","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase M.","family":"Heaton","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick K.","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-7476","authenticated-orcid":false,"given":"Sue S.","family":"Yom","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California San Francisco San Francisco California"},{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.11.037"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12707"},{"key":"e_1_2_7_4_1","unstructured":"National Comprehensive Cancer Network.Squamous Cell Skin Cancer \u2010 version 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