{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:33:13Z","timestamp":1777620793413,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Commission of Shanghai Municipality of China","award":["15401971600"],"award-info":[{"award-number":["15401971600"]}]},{"name":"Traditional Chinese Medicine scientific research of Health and Family Planning Commission of Shanghai Municipality of China","award":["2016LP019"],"award-info":[{"award-number":["2016LP019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have indicated the larynx as possible Helicobacter pylori (<jats:italic>H. pylori<\/jats:italic>) reservoirs. This study explored the association between <jats:italic>H. pylori<\/jats:italic> and vocal fold leukoplakia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The case\u2010control study involved 51 patients with vocal fold leukoplakia and 35 control patients with vocal polyps. Helicobacter pylori was detected in tissues by the rapid urease test, nested polymerase chain reaction (PCR), and single\u2010step PCR. The <jats:italic>H. pylori<\/jats:italic>\u2010specific immunoglobulin antibodies were detected in plasma by enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Helicobacter pylori\u2010positive rate of vocal fold leukoplakia and vocal polyps was 23.5% versus 11.4% (<jats:italic>P<\/jats:italic> = .157), 37.2% versus 14.3% (<jats:italic>P<\/jats:italic> = .020), 27.5% versus 8.6% (<jats:italic>P<\/jats:italic> = .031), and 70.6% versus 68.6% (<jats:italic>P<\/jats:italic> = .841) detected by rapid urease test, nested PCR, single\u2010step PCR, and ELISA, respectively. Regression analysis indicated that <jats:italic>H. pylori<\/jats:italic> infection (<jats:italic>P<\/jats:italic> = .044) was the independent risk factor for vocal fold leukoplakia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Helicobacter pylori infection exists in the larynx and may be associated with vocal fold leukoplakia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25121","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T14:47:48Z","timestamp":1520347668000},"page":"1498-1507","source":"Crossref","is-referenced-by-count":16,"title":["Possible association between Helicobacter pylori infection and vocal fold leukoplakia"],"prefix":"10.1002","volume":"40","author":[{"given":"Min","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital Fudan University Shanghai China"},{"name":"Shanghai Key Clinical Disciplines of 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