{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T11:30:51Z","timestamp":1760441451260,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to investigate the association between isolated serous otitis media (SOM) and\/or conductive hearing loss (CHL) and nasopharyngeal carcinoma (NPC) in a low\u2010to\u2010intermediate endemic area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of all adult patients (\u226517 years) with SOM\/CHL who underwent endoscopic\u2010guided nasopharyngeal biopsy to exclude NPC during a 10\u2010year period were reviewed. Statistical analyses were conducted to identify significant predictors for NPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 195 patients were included (121\/195; 62.1% men), among whom 169 (86.7%) presented with isolated SOM\/CHL. Overall, 12 patients were diagnosed with NPC (12\/195; 6.2%), however, only 1 patient (1\/169; 0.6%) had isolated SOM\/CHL. Coexisting clinical manifestations and suspicious nasopharyngeal findings on fiber\u2010optic nasopharyngoscopy were found to be significant predictors for NPC on univariate and multivariate analyses (<jats:italic>P<\/jats:italic> &lt; .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with isolated SOM\/CHL and without coexisting clinical manifestations or suspicious findings on nasopharyngoscopy may avoid a routine nasopharyngeal biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25135","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T12:16:32Z","timestamp":1521116192000},"page":"1565-1572","source":"Crossref","is-referenced-by-count":4,"title":["Nasopharyngeal biopsy in adults presenting with serous otitis media: Cross\u2010sectional study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6474-7435","authenticated-orcid":false,"given":"Shahaf","family":"Shilo","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2546-1757","authenticated-orcid":false,"given":"Sara","family":"Abu\u2010Ghanem","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Yehuda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery and 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