{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:13:53Z","timestamp":1790748833623,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Smoking and alcohol increase the risk of head and neck cancer and affect treatment outcomes. Interventions modifying these behaviors may improve posttreatment outcomes and survival. We systematically reviewed evidence of the effectiveness of smoking\/alcohol interventions in head and neck cancer and oral dysplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The AMED, CINAHL, Embase, MEDLINE, and Web of Science databases were searched for randomized controlled trials (RCTs) of smoking\/alcohol interventions in people with head and neck cancer. A qualitative synthesis of the studies was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three RCTs were identified: 2 smoking interventions and 1 smoking and alcohol intervention. One intervention, which was comprised of a smoking intervention based on Cognitive Behavioral Therapy and pharmacologic management compared to usual care, reduced smoking prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Further research is required into the underlying mechanisms that lead to cessation and interventions that include both pharmacological and behavioral therapy. Future RCTs should include suitable control conditions and sufficient power to assess clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25138","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T06:39:40Z","timestamp":1522478380000},"page":"1845-1853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Systematic review evaluating randomized controlled trials of smoking and alcohol cessation interventions in people with head and neck cancer and oral dysplasia"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7332-5362","authenticated-orcid":false,"given":"Ellie","family":"Shingler","sequence":"first","affiliation":[{"name":"National Institute for Health Research (NIHR), Bristol Biomedical Research Centre (BRC) Nutrition Theme University of Bristol Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke A.","family":"Robles","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR), Bristol Biomedical Research Centre (BRC) Nutrition Theme University of Bristol Bristol United Kingdom"},{"name":"Bristol Medical School: Population Health Sciences University of Bristol Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Perry","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR), Bristol Biomedical Research Centre (BRC) Nutrition Theme University of Bristol Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-353X","authenticated-orcid":false,"given":"Chris","family":"Penfold","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR), Bristol Biomedical Research Centre (BRC) Nutrition Theme University of Bristol Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy R.","family":"Ness","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR), Bristol Biomedical Research Centre (BRC) Nutrition Theme University of Bristol Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery University of Bristol Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Athene","family":"Lane","sequence":"additional","affiliation":[{"name":"Bristol Medical School: Population Health Sciences University of Bristol Bristol United Kingdom"},{"name":"Department of Randomised Trials Collaboration University of Bristol, School of Social and Community Medicine Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Martin","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR), Bristol Biomedical Research Centre (BRC) Nutrition Theme University of Bristol Bristol United Kingdom"},{"name":"Bristol Medical School: Population Health Sciences University of Bristol Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"NHS Choices.Head and Neck Cancer.2016.http:\/\/www.nhs.uk\/conditions\/cancer\u2010of\u2010the\u2010head\u2010and\u2010neck\/Pages\/Definition.aspx. Accessed April 26 2016."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_8_4_1","unstructured":"Oxford Cancer Intelligence Unit (OCIU).Profile of Head and Neck Cancers in England: Incidence Mortality and Survival.http:\/\/www.ncin.org.uk\/cancer_type_and_topic_specific_work\/cancer_type_specific_work\/head_and_neck_cancers\/head_and_neck_cancer_hub\/resources. National Cancer Intelligence Network; 2010. Accessed April 26 2016."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2012.02.013"},{"issue":"5","key":"e_1_2_8_6_1","first-page":"406","article-title":"Epithelial dysplasia in oral cavity","volume":"39","author":"Shirani S","year":"2014","journal-title":"Iran J Med Sci."},{"key":"e_1_2_8_7_1","unstructured":"Cancer Research UK (CRUK).Types of mouth and oropharyngeal cancer.http:\/\/www.cancerresearchuk.org\/about\u2010cancer\/type\/mouth\u2010cancer\/about\/types\u2010of\u2010mouth\u2010and\u2010oropharyngeal\u2010cancer#pre. 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