{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:34:38Z","timestamp":1769582078730,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>As per TNM classification, superficial tumors with a favorable prognosis are fallaciously clubbed together with unfavorable, deeply infiltrating lesions in the same classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study of 588 patients with treatment\u2010naive oral tongue cancers. Binary logistic regression was used to identify predictors of nodal metastasis and extracapsular spread (ECS) using tumor volume and thickness as separate models. The C\u2010index was generated to quantify predictive accuracy of T classification, thickness, and tumor volume for survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to T classification, tumor volume and thickness were better predictors of nodal metastasis and ECS. Predictive accuracy for disease\u2010free survival (DFS) and overall survival (OS) given by C\u2010index was equal and better for thickness (0.60 and 0.69) and tumor volume (0.61 and 0.69) as compared to T classification (0.59 and 0.64, respectively). For early\u2010stage T1 to T2 oral tongue cancer, thickness is a better predictor of nodal metastasis as compared to tumor volume and T classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Concordance between the tumor thickness and volume proves that tumor thickness can be taken as a surrogate and reliable predictor of outcomes instead of calculating the tumor volume.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25161","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T16:49:23Z","timestamp":1525711763000},"page":"1667-1675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of tumor volume, thickness, and T classification as predictors of outcomes in surgically treated squamous cell carcinoma of the oral tongue"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-2738","authenticated-orcid":false,"given":"Manish","family":"Mair","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshat","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aseem","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadhana","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0554-4184","authenticated-orcid":false,"given":"Saurabh","family":"Bobdey","sequence":"additional","affiliation":[{"name":"Department of Medical Records, Biostatistics and Epidemiology Tata Memorial Hospital Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitesh","family":"Singhvi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncosurgery Tata Memorial Hospital Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)01378-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19851001)56:7<1597::AID-CNCR2820560722>3.0.CO;2-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11202"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0678-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.09.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890030020004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24161"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90562-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(200005)22:3<282::AID-HED11>3.0.CO;2-K"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90016-O"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931015)72:8<2383::AID-CNCR2820720815>3.0.CO;2-B"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20254"},{"key":"e_1_2_6_14_1","unstructured":"Annotated SPSS Output: Logistic Regression [Internet].http:\/\/www.ats.ucla.edu\/stat\/spss\/output\/logistic.htm. 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