{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:19:55Z","timestamp":1762431595322,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to determine the factors affecting local control in patients with T1N0 squamous cell carcinoma (SCC) of the tongue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of 144 patients with pT1N0 SCC of the tongue who underwent wide excision and neck dissection without adjuvant therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The adverse pathological features associated with local control were least margin 5 mm (<jats:italic>P<\/jats:italic> = .004), infiltrative margin (<jats:italic>P<\/jats:italic> = .403), depth &gt;4 mm (<jats:italic>P<\/jats:italic> = .136), lymphovascular invasion (<jats:italic>P<\/jats:italic> = .301), and perineural invasion (<jats:italic>P<\/jats:italic> = .342). We derived a scoring system of 10 points based on the hazard ratio for local failure; those with scores &gt;5 points had a 5\u2010year local control of &lt;60%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests patients having a margin of 5 mm need revision, however, if they do not have additional adverse pathological features (score \u22644), local control is 88% at 5 years, and they may be observed. Those who have margins over 5 mm with a total score &gt;5 may still benefit from adjuvant therapy. Those with margins over 5 mm have improved local control (<jats:italic>P<\/jats:italic> = .029).<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25163","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T08:04:22Z","timestamp":1541059462000},"page":"2329-2333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Role of adverse pathological features in surgically treated early oral cavity carcinomas with adequate margins and the development of a scoring system to predict local control"],"prefix":"10.1002","volume":"40","author":[{"given":"Narayana","family":"Subramaniam","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncology Amrita Institute of Medical Sciences Kerala 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