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The purpose of this study was to document the extent and timing of dysphagia and related toxicities during helical intensity\u2010modulated radiotherapy (IMRT) with chemotherapy for oropharyngeal squamous cell carcinoma (SCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective study of 76 patients with oropharyngeal SCC undergoing helical IMRT with chemotherapy. Dysphagia and acute toxicity data were collected weekly during treatment and at 2, 4, and 12 weeks posttreatment using the Functional Oral Intake Scale, diet descriptors, and Common Terminology Criteria for Adverse Events (CTCAE) version 4.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients experienced maximum incidence of grade 3 dysphagia (61%), mucositis (30%), and thick saliva (38%), with grade 2 xerostomia (87%) and dysgeusia (97%). Only 14.5% were nil\u2010by\u2010mouth. Symptoms peaked in week 7 and improved thereafter. Grade 3 dysphagia was twice as common for T3 to T4 tumors compared with T2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results confirm that patients with oropharyngeal SCC undergoing helical IMRT with chemotherapy continue to experience incidences of acute toxicities comparable with other conformal techniques, and need supportive cares.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25182","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T05:45:27Z","timestamp":1526276727000},"page":"1955-1966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Helical intensity\u2010modulated radiotherapy with concurrent chemotherapy for oropharyngeal squamous cell carcinoma: A prospective investigation of acute swallowing and toxicity patterns"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-907X","authenticated-orcid":false,"given":"Laura B.","family":"Moroney","sequence":"first","affiliation":[{"name":"Department of Speech Pathology and Audiology Royal Brisbane and Women's Hospital Brisbane Australia"},{"name":"The University of Queensland School of Health and Rehabilitation Sciences Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Helios","sequence":"additional","affiliation":[{"name":"Department of Speech Pathology and Audiology Royal Brisbane and Women's Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth C.","family":"Ward","sequence":"additional","affiliation":[{"name":"The University of Queensland School of Health and Rehabilitation Sciences Brisbane Australia"},{"name":"Centre for Functioning and Health Research Metro South Hospital and Health Service Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Crombie","sequence":"additional","affiliation":[{"name":"Department of Speech Pathology and Audiology Royal Brisbane and Women's Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Pelecanos","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare L.","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Speech Pathology and Audiology Royal Brisbane and Women's Hospital Brisbane Australia"},{"name":"The University of Queensland School of Health and Rehabilitation Sciences Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann\u2010Louise","family":"Spurgin","sequence":"additional","affiliation":[{"name":"Department of Speech Pathology and Audiology Royal Brisbane and Women's Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Blake","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Royal Brisbane and Women's Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizbeth","family":"Kenny","sequence":"additional","affiliation":[{"name":"Department of Speech Pathology and Audiology Royal Brisbane and Women's Hospital Brisbane Australia"},{"name":"Department of Nutrition and Dietetics Royal Brisbane and Women's Hospital Brisbane Australia"},{"name":"The University of Queensland, School of Medicine Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Speech Pathology and Audiology Royal Brisbane and Women's Hospital Brisbane Australia"},{"name":"Department of Nutrition and Dietetics Royal Brisbane and Women's Hospital Brisbane Australia"},{"name":"The University of Queensland, School of Medicine Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett G. 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