{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:48:22Z","timestamp":1769816902486,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purposes of this study were to describe the characteristics of a prospective multicenter series of patients with salivary duct carcinoma and to investigate prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients included for salivary duct carcinoma between 2009 and 2016 in the R\u00e9seau d'Expertise Fran\u00e7ais des Cancers ORL Rares (REFCOR) database were selected. Immunohistochemical analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients were included in this study. The primary site was the parotid gland in 90% of the cases. Fifty\u2010seven percent of the tumors were stage IV, 65% of patients had lymph node involvement, and 10% had metastases. Tumors showed androgen receptor (89%) and human epidermal growth factor receptor 2 (HER2)\/neu (36%). Ninety\u2010four percent of patients underwent surgery and 86% had postoperative radiotherapy. Six patients were treated with targeted therapies. The 3\u2010year overall survival (OS) was 74% and the 3\u2010year disease\u2010free survival (DFS) was 44%. Tumor stages III to IV reduced DFS (hazard ratio [HR] 4.3; <jats:italic>P<\/jats:italic> = .04). The N2\/3 class reduced distant metastasis\u2010free survival (HR 7.3; <jats:italic>P<\/jats:italic> = .007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Salivary duct carcinoma prognosis is poor and is correlated with tumor stage and lymph node classification. Androgen receptor and HER2\/neu should be tested as they offer the possibility of targeted therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25194","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T12:41:21Z","timestamp":1542112881000},"page":"584-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Salivary duct carcinoma: Prospective multicenter study of 61 cases of the R\u00e9seau d'Expertise Fran\u00e7ais des Cancers ORL Rares"],"prefix":"10.1002","volume":"41","author":[{"given":"Aude","family":"Villepelet","sequence":"first","affiliation":[{"name":"Service d'ORL et de Chirurgie Cervicofaciale, H\u00f4pital Tenon Assistance Publique\u2010H\u00f4pitaux de Paris, Paris \/ Universit\u00e9 Pierre et Marie Curie, Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Lef\u00e8vre","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique, H\u00f4pital Tenon Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Verillaud","sequence":"additional","affiliation":[{"name":"Service d'ORL et de Chirurgie Cervicofaciale, H\u00f4pital Lariboisi\u00e8re Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Janot","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'ORL et de Chirurgie Cervicofaciale Institut Gustave\u2010Roussy, Villejuif  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Garrel","sequence":"additional","affiliation":[{"name":"Service d'ORL et de Chirurgie Cervicofaciale CHU de Montpellier  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Vergez","sequence":"additional","affiliation":[{"name":"Service d'ORL et de Chirurgie Cervicofaciale IUC Toulouse  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chlo\u00e9","family":"Bertolus","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Maxillofaciale, H\u00f4pital Piti\u00e9 Salp\u00e9tri\u00e8re Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Malard","sequence":"additional","affiliation":[{"name":"Service d'ORL et de Chirurgie Cervicofaciale CHU de Nantes  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic","family":"de Gabory","sequence":"additional","affiliation":[{"name":"Service d'ORL et de Chirurgie Cervicofaciale CHU de Bordeaux  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4146-3565","authenticated-orcid":false,"given":"Olivier","family":"Mauvais","sequence":"additional","affiliation":[{"name":"Service d'ORL et de Chirurgie Cervicofaciale CHU de Besan\u00e7on  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-3191","authenticated-orcid":false,"given":"Bertrand","family":"Baujat","sequence":"additional","affiliation":[{"name":"Service d'ORL et de Chirurgie Cervicofaciale, H\u00f4pital Tenon Assistance Publique\u2010H\u00f4pitaux de Paris, Paris \/ Universit\u00e9 Pierre et Marie Curie, Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the REFCOR members","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-84506-2"},{"key":"e_1_2_7_3_1","first-page":"454","article-title":"Salivary duct carcinoma of the parotid gland. Cytologic and histopathologic study","volume":"29","author":"Gal R","year":"1985","journal-title":"Acta Cytol."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00301495"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0456-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24332"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3180caa099"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000413"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21116"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-014-0674-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960115)77:2<223::AID-CNCR1>3.0.CO;2-N"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24107"},{"key":"e_1_2_7_13_1","first-page":"342","article-title":"Histopathological case report of high grade salivary duct carcinoma","volume":"53","author":"Borovec J","year":"2015","journal-title":"Folia Histochem Cytobiol Pol Acad Sci Pol Histochem Cytochem Soc."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199703)19:2<126::AID-HED7>3.0.CO;2-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/PAI.0b013e31802e91b2","article-title":"Her\u20102\/neu expression in salivary duct carcinoma: an immunohistochemical and chromogenic in situ hybridization study","volume":"16","author":"Johnson CJ","year":"2008","journal-title":"Appl Immunohistochem Mol Morphol."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2015.11.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890090304"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900515)65:10<2307::AID-CNCR2820651024>3.0.CO;2-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930901)72:5<1503::AID-CNCR2820720503>3.0.CO;2-K"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930540315"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(94)90119-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb01440.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980301386-X"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-012-1014-z"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/21574486"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-1997-4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrt026"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.08.010"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0953-SA"},{"key":"e_1_2_7_30_1","volume-title":"R: a language and environment for statistical computing","author":"R development Core Team","year":"2007"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.3930"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2015.04.005"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-5082-2"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23350"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12426"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.08.001"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816636812"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.8351"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23383"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2014.07.007"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23940"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2568"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00097-6"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20614"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20714"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-9884-1"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.11.014"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0369"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23307"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23429"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1842"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0637"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.2095"},{"key":"e_1_2_7_54_1","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2016.34.15_suppl.6086","article-title":"PACSA: phase II study of pazopanib in patients with progressive recurrent or metastatic salivary gland carcinoma","volume":"34","author":"Guigay J","year":"2016","journal-title":"J Clin Oncol."},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602252"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.10.020"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.25194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:42:07Z","timestamp":1694684527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/hed.25194"],"URL":"https:\/\/doi.org\/10.1002\/hed.25194","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,13]]},"assertion":[{"value":"2017-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}