{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:38:44Z","timestamp":1788547124880,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T00:00:00Z","timestamp":1526169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The benefit of CT for the diagnosis of lymph node metastasis in patients with thyroid cancer is still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred fifty\u2010one patients with thyroid cancers from 7 hospitals were prospectively enrolled in order to compare diagnostic performance between a combination of ultrasound and CT (ultrasound\/CT) and ultrasound alone for prediction of lymph node metastasis and to calculate patient\u2010based benefits of CT added to ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 801 pathologically proven neck levels, ultrasound\/CT showed higher sensitivities in both central and lateral compartments and improved accuracy in the lateral compartment compared to ultrasound alone. In the retropharyngeal\/superior mediastinal compartment, although CT could detect lymph node metastasis an ultrasound could not. Patient\u2010based benefit was demonstrated in 13.1% of patients (46\/351), and was higher in patients with cancers &gt;1 cm than cancers \u22641 cm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with thyroid cancer, CT improved surgical planning by enhancing the sensitivity for lymph node metastasis and by detecting lymph node metastasis that was overlooked with ultrasound alone.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25202","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T05:47:19Z","timestamp":1526276839000},"page":"2137-2148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Value of CT added to ultrasonography for the diagnosis of lymph node metastasis in patients with thyroid cancer"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7739-4173","authenticated-orcid":false,"given":"Younghen","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiology Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6349-6950","authenticated-orcid":false,"given":"Ji\u2010hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University Hospital and College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hwan","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology, Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3267-8399","authenticated-orcid":false,"given":"So Lyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul St Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5063-2685","authenticated-orcid":false,"given":"Sun\u2010Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology, Boramae Medical Center, College of Medicine Seoul National University and College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinna","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Severance Hospital, Research Institute of Radiological Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Jin","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University Hospital and College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ju","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology, Asan Medical Center University of Ulsan College of Medicine Seoul Korea"},{"name":"Department of Radiology Ajou University School of Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University Hospital and College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Young","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Sook","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6422-1652","authenticated-orcid":false,"given":"Dong Gyu","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Radiology Gang Neung Asan Hospital Gangneung\u2010si Korea"},{"name":"Department of Radiology Human Medical Imaging and Intervention Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0392"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.14366\/usg.15027"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.4.7407"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0063"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0312"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3401"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0098"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0096"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0043"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0121"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9724-x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.16.3.468"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2016.17.3.370"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04336.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04162.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2012.01.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23277"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1527-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0269"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2386"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9588-7"},{"key":"e_1_2_6_25_1","first-page":"87","volume-title":"AJCC Cancer Staging Manual","author":"Edge S","year":"2010"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0159"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHLWMI3JV4LA"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.33.2.366"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2011.12.1.1"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2015.16.2.391"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0415"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.04.084"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2013.04.003"},{"key":"e_1_2_6_34_1","first-page":"872","volume-title":"AJCC Cancer Staging Manual","author":"Amin MB","year":"2016"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.254"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K09E-025"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21653"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0238"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2008.04.005"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0444"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.25202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T01:05:05Z","timestamp":1694826305000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,13]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/hed.25202"],"URL":"https:\/\/doi.org\/10.1002\/hed.25202","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,13]]},"assertion":[{"value":"2017-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}