{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:15:42Z","timestamp":1761293742662,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T00:00:00Z","timestamp":1526169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary intestinal\u2010type adenocarcinoma (ITAC) of the oral tongue is an extremely uncommon malignancy with only 3 cases reported in the literature. This high\u2010grade malignancy originates from metaplasia of minor salivary glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 40\u2010year\u2010old man presented with a gradually enlarging midline oral tongue mass, odynophagia, and dysphagia. Management included a median lingual glossectomy, bilateral neck dissections, and adjuvant chemoradiation with 5\u2010fluorouracil (5\u2010FU). Additional chemotherapy with folinic acid, fluorouracil, and oxaliplatin (FOLFOX) was given to mimic therapy in colonic adenocarcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen months after surgery and adjuvant chemoradiotherapy, there is no evidence of locoregional or distant disease. His diet and speech have normalized after reconstruction without free tissue transfer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report the fourth case of oral tongue ITAC, and present the first histologic evidence of metaplasia of oral cavity salivary epithelium. We also discuss adjuvant therapy recommendations given the lack of clarity for treatment of this rare disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25203","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T05:47:19Z","timestamp":1526276839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Primary intestinal\u2010type adenocarcinoma of the oral tongue: Case report and review of histologic origin and oncologic management"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2286-9749","authenticated-orcid":false,"given":"Jenna","family":"Berg","sequence":"first","affiliation":[{"name":"University of Nebraska Medical Center, College of Medicine Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo E.","family":"Manosalva","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Naval Medical Center Portsmouth Portsmouth Virginia"},{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery United States Naval Hospital Okinawa Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Coughlin","sequence":"additional","affiliation":[{"name":"Nebraska Methodist Hospital Estabrook Cancer Center Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yungpo Bernard","family":"Su","sequence":"additional","affiliation":[{"name":"Nebraska Methodist Hospital Estabrook Cancer Center Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien\u2010Shew","family":"Huang","sequence":"additional","affiliation":[{"name":"Nebraska Methodist Hospital Estabrook Cancer Center Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Gentry","sequence":"additional","affiliation":[{"name":"Nebraska Methodist Hospital Estabrook Cancer Center Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,13]]},"reference":[{"volume-title":"World Health Organization Classification of Tumors. Pathology and Genetics of Head and Neck Tumors","year":"2005","author":"Barnes L","key":"e_1_2_7_2_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.humpath.2003.08.024"},{"issue":"4","key":"e_1_2_7_4_1","first-page":"365","article-title":"Mucosal origin of sinonasal tract adenomatous neoplasms","volume":"2","author":"Gnepp DR","year":"1989","journal-title":"Mod Pathol."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0800-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.01.028"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-011-0301-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.3240a"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0759-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0740-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.7.717"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24416"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjt134"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032641"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032646"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.25203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:58:30Z","timestamp":1694357910000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,13]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/hed.25203"],"URL":"https:\/\/doi.org\/10.1002\/hed.25203","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"type":"print","value":"1043-3074"},{"type":"electronic","value":"1097-0347"}],"subject":[],"published":{"date-parts":[[2018,5,13]]},"assertion":[{"value":"2017-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}