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Interleukin\u201017F (IL\u201017F) plays a protective role in many tumors. However, IL\u201017F expression in oral tongue SCC tissue has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunostaining of 83 oral tongue SCC specimens and blinded\u2010scoring were used to map IL\u201017F expression, location, and distribution. Survival curves were constructed according to Kaplan\u2010Meier method. The Cox proportional hazard model was applied for univariate and multivariate survival analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mast cells are the major source of IL\u201017F in oral tongue SCC. In multivariate analysis, only the extracellular mast cell\u2010derived IL\u201017F at the tumor invasion front was associated with better disease\u2010specific survival in patients with all\u2010stages and early\u2010stages of oral tongue SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Extracellular mast cell\u2010derived IL\u201017F is antitumorigenic in oral tongue SCC. It separates patients with early\u2010stage disease who are at high risk from patients who are at low risk. Furthermore, when analyzing tentative prognostic molecules, we conclude that in addition to the staining intensity, attention must be paid to the cellular source, distribution, and location of the molecule.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25207","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T05:46:07Z","timestamp":1526363167000},"page":"2155-2165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Extracellular interleukin\u201017F has a protective effect in oral tongue squamous cell carcinoma"],"prefix":"10.1002","volume":"40","author":[{"given":"Rabeia","family":"Almahmoudi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Clinicum University of Helsinki Helsinki 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