{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:17:10Z","timestamp":1790806630240,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T00:00:00Z","timestamp":1526169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and\/or radiation exhibited the best overall survival when compared to monotherapy and no treatment (<jats:italic>P<\/jats:italic> &lt; .001). However, most patients (66%) received either monotherapy or no therapy. The number and location of metastases among the 3 treatment groups did not significantly differ (<jats:italic>P<\/jats:italic> = .85). Treatment modality remained significantly associated with overall survival on multivariable analysis (<jats:italic>P<\/jats:italic> &lt; .001). Platinum\u2010based chemotherapy was most commonly utilized but did not provide a survival benefit when compared with all other regimens (<jats:italic>P<\/jats:italic> = .88).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Distant metastases with esthesioneuroblastoma portend a poor prognosis. Chemotherapy in combination with surgery and\/or radiation was associated with improved overall survival. Further research into the optimal systemic therapeutic regimen for patients with distant metastases is critical.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25209","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T05:50:20Z","timestamp":1526277020000},"page":"2295-2303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Esthesioneuroblastoma with distant metastases: Systematic review &amp; meta\u2010analysis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2350-8942","authenticated-orcid":false,"given":"John P.","family":"Marinelli","sequence":"first","affiliation":[{"name":"Mayo Clinic School of Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Janus","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Mayo Clinic 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