{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:08:09Z","timestamp":1766066889421},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>First bite syndrome is a well\u2010recognized complication of parapharyngeal space surgery. There are no reported cases of protracted first bite syndrome and subsequent diagnosis of a primary squamous cell carcinoma (SCC) of the parotid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present the case of a 73\u2010year\u2010old man with no surgical history and 9 years of first bite syndrome who was ultimately diagnosed with a primary SCC of the parotid. Diagnostic workup, including MRI and biopsy, along with oncologic treatment, were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Surgical treatment confirmed malignancy and also resulted in complete resolution of the first bite syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>First bite syndrome without prior surgery may warrant further diagnostic workup with imaging to evaluate for salivary gland pathology. When no radiographic mass lesion is detected but the patient displays protracted symptoms unresponsive to conservative therapy, one should maintain an index of suspicion for malignancy, especially in the presence of symptom escalation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25321","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T09:52:34Z","timestamp":1529574754000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Chronic atypical first bite syndrome and primary squamous cell carcinoma of the parotid"],"prefix":"10.1002","volume":"40","author":[{"given":"Maheer M.","family":"Masood","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of North Carolina School of Medicine Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano Di","family":"Giosia","sequence":"additional","affiliation":[{"name":"Orofacial Pain Clinic\u2010Department of Endodontics University of North Carolina School of Dentistry Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor G.","family":"Hackman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of North Carolina School of Medicine Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23725"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21282"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21412"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2009.10.035"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2016.07.012"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21054"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042533312472115"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-42-14"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2001.28068"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221511000294X"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.12.024"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.06.007"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5506"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013361"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-10-117"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20360"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2262011486"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2007.0008"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.25321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T20:03:15Z","timestamp":1694980995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,21]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/hed.25321"],"URL":"https:\/\/doi.org\/10.1002\/hed.25321","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,21]]},"assertion":[{"value":"2017-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}