{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:09:30Z","timestamp":1747148970859,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH\u2010C106\u2010041"],"award-info":[{"award-number":["TSGH\u2010C106\u2010041"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to present our comparison of the clinical outcome of patients with nasopharyngeal carcinoma (NPC) treated with whole\u2010field intensity\u2010modulated radiotherapy (whole\u2010field\u2010IMRT) or split\u2010field\u2010IMRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied 388 patients with M0 NPC. The median lower neck doses were 50 Gy in 1.35 Gy\/fractions for the 240 whole\u2010field\u2010IMRT patients, and 50.4 Gy in 1.8 to 2.0 Gy\/fractions for the 148 split\u2010field\u2010IMRT patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IMRT technique did not affect the overall survival (OS; <jats:italic>P<\/jats:italic> = .077) and locoregional control (<jats:italic>P<\/jats:italic> = .231) rates. However, the split\u2010field\u2010IMRT group had more locoregional recurrences at the whole neck (<jats:italic>P<\/jats:italic> = .005) but not at the nasopharynx (<jats:italic>P<\/jats:italic> = .968) or the lower neck (<jats:italic>P<\/jats:italic> = .485). The patients treated with split\u2010field\u2010IMRT (43.2%) had more grade III neck fibrosis than the patients who received whole\u2010field\u2010IMRT (18.3%; <jats:italic>P<\/jats:italic> &lt; .001). Only 1 patient had temporal lobe necrosis in our study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that whole\u2010field\u2010IMRT using a lower dose\/fraction for the lower neck results in at least comparable locoregional control and less fibrosis compared to conventional fraction with split\u2010field\u2010IMRT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25328","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:48:13Z","timestamp":1546296493000},"page":"598-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment outcomes with whole\u2010field versus split\u2010field intensity\u2010modulated radiotherapy for patients with nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1919-8769","authenticated-orcid":false,"given":"Chun\u2010Shu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-7088","authenticated-orcid":false,"given":"Yuan\u2010Wu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9730-1798","authenticated-orcid":false,"given":"Shao\u2010Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Cheng","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuen\u2010Tze","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve P.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, David Geffen School of Medicine University of California Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Yueh","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Yueh","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Chien","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tri\u2010Service General Hospital National Defense Medical Center Taipei 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