{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:48:50Z","timestamp":1790275730698,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study analyzed the expression of CD44 and cystine\u2010glutamate transporter SLC7A11 (xCT) in primary oral cavity squamous cell carcinoma (SCC) and the relationships of expression to tumor recurrence and patient survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Associations between CD44 and xCT expression and clinicopathologic results were analyzed in 231 patients with oral cavity SCC. Cox proportional hazard analyses were used to identify factors associated with recurrence\u2010free survival (RFS), disease\u2010specific survival (DSS), and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overexpression of CD44 and\/or xCT was associated with advanced T classification, perineural invasion, and lymphovascular invasion (<jats:italic>P<\/jats:italic> &lt; .05 each). High expression of xCT was also associated with nodal metastasis and depth of invasion (<jats:italic>P<\/jats:italic> &lt; .01 each). Multivariate analysis indicated that high expression of xCT and both xCT and CD44 were independent predictors of poor RFS, DSS, and OS (<jats:italic>P<\/jats:italic> &lt; .05 each).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overexpression of xCT or xCT plus CD44 may predict posttreatment recurrence and survival in patients with oral cavity SCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25331","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T18:04:16Z","timestamp":1539194656000},"page":"2340-2346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Overexpression of cysteine\u2010glutamate transporter and CD44 for prediction of recurrence and survival in patients with oral cavity squamous cell carcinoma"],"prefix":"10.1002","volume":"40","author":[{"given":"Jae Ryung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Keimyung University Dongsan Medical Center  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3636-954X","authenticated-orcid":false,"given":"Jong\u2010Lyel","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangsoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Ja","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Yuhl","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2929"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2015.01123"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30107"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0048"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.01.038"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4391"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4267"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23527"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.33"},{"key":"e_1_2_6_14_1","unstructured":"National Comprehensive Cancer Network (NCCN).Clinical Practice Guidelines in Oncology: Head and Neck Cancers. 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