{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T16:32:46Z","timestamp":1775493166068,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pharyngocutaneous fistula is a major wound complication of total laryngectomy. Surgical sealants may be used to increase the strength and\/or integrity of surgical repairs. The purpose of this study was to present our evaluation of the feasibility and utility of the application of sealant to the pharyngeal repair with the aim of reducing pharyngocutaneous fistula incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective single\u2010blind randomized controlled study; patients undergoing primary total laryngectomy for advanced carcinoma of the larynx were randomized into control and treatment (albumin\u2010polyaldehyde sealant applied to pharyngeal repair) groups. Relevant patient, disease, and management\u2010related factors were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five patients were included (23 controls and 22 who received treatments). No difference in the incidence of pharyngocutaneous fistula was observed between the 2 groups. No treatment\u2010related complications occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Feasibility of application of an albumin\u2010polyaldehyde surgical sealant to the pharyngeal repair was demonstrated, however, a pharyngocutaneous fistula\u2010preventative effect was not observed. Larger animal and clinical studies are encouraged to clarify this finding.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25334","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T05:44:44Z","timestamp":1543470284000},"page":"2606-2611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Use of surgical sealant in the prevention of pharyngocutaneous fistula after total laryngectomy"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7061-1841","authenticated-orcid":false,"given":"Kate A.","family":"Stephenson","sequence":"first","affiliation":[{"name":"Division of Otorhinolaryngology Frere Hospital  East London South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarita","family":"Pandey","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology Frere Hospital  East London South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darlene E.","family":"Lubbe","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes J.","family":"Fagan","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.12.1317"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100103421"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.1.67"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24448"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200101)23:1<29::AID-HED5>3.0.CO;2-P"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26454"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2015.04.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2015.06.012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0431-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.10.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1244165"},{"key":"e_1_2_7_13_1","first-page":"Doc01","article-title":"Tissue adhesives in otorhinolaryngology","volume":"8","author":"Schneider G","year":"2009","journal-title":"GMS Curr Top Otorhinolaryngol Head Neck Surg."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2002.126318"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-6519(08)75516-X"},{"issue":"3","key":"e_1_2_7_16_1","first-page":"239","article-title":"[Pharmacological prophylaxis of gastroesophageal reflux. 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