{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:20:04Z","timestamp":1780086004514,"version":"3.54.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is little population\u2010level data evaluating risk factors for postoperative complications after total laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of the American College of Surgeons National Quality Improvement Program identifying patients who underwent total laryngectomy as a primary procedure from 2005 to 2014. Multivariate analysis was performed to identify variables that were independently associated with overall and major complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight hundred seventy\u2010one cases met inclusion criteria. Three hundred twenty\u2010eight patients (37.7%) had complications, with operative time (hours; <jats:italic>P<\/jats:italic> &lt; .0001), class III (<jats:italic>P<\/jats:italic> &lt; .001) wound status, and patient age (decade; <jats:italic>P<\/jats:italic> = .003) associated with overall complications. Two hundred one patients had major complications that were associated with steroid use (<jats:italic>P<\/jats:italic> = .01) and class III (<jats:italic>P<\/jats:italic> = .0083) wound classification. Preoperative hematocrit was correlated with a reduction of all and major complications on multivariate analysis (<jats:italic>P<\/jats:italic> &lt; .0001 and <jats:italic>P<\/jats:italic> = .036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Identifying and optimizing risk factors may improve outcomes in total laryngectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25363","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T14:21:58Z","timestamp":1539267718000},"page":"2409-2415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Factors associated with complications in total laryngectomy without microvascular reconstruction"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3284-6946","authenticated-orcid":false,"given":"Samuel N.","family":"Helman","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery New York Eye and Ear Infirmary of Mount Sinai  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Brant","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameep K.","family":"Kadakia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery New York Eye and Ear Infirmary of Mount Sinai  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven B.","family":"Cannady","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond L.","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2003.11.017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813505078"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21352"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.16092"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198105000-00001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100079433"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26039"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13399"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0902.020232"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.12.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816686958"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.08.004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/2000656X.2015.1106407"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.09.018"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12307"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-2092(06)60559-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.122704"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24669"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180de4d85"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814528451"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.08.028"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.5.505"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-016-2262-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20974"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30483"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813511785"}],"container-title":["Head &amp; 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