{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:30:15Z","timestamp":1776310215196,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Succinate dehydrogenase subunit B (SDHB) immunohistochemistry was considered a valuable tool to identify patients with inherited paraganglioma\/pheochromocytoma (PGL\/PCC). However, previous studies jointly analyzed 2 related but clinically distinct entities, parasympathetic head and neck paragangliomas (HNPGLs) and sympathetic PCCs\/PGLs. Additionally, a role for hypoxia inducible factor\u20101\u03b1 (HIF\u20101\u03b1) as a biomarker for succinate dehydrogenase (<jats:italic>SDHx<\/jats:italic>)\u2010mutated tumors has not been studied. Here, we evaluated the utility of SDHB\/HIF\u20101\u03b1 proteins in HNPGLs and PCCs\/PGLs as clinically useful biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The SDHB\/succinate dehydrogenase subunit A (SDHA)\/HIF\u20101\u03b1 immunohistochemistry analysis was performed in 158 genetically defined patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Similarly to PCCs\/PGLs, SDHB immune\u2010negativity correlated with <jats:italic>SDHx<\/jats:italic>\u2010mutations in HNPGLs (<jats:italic>P<\/jats:italic> &lt; .0001). The HIF\u20101\u03b1 stabilization was associated with <jats:italic>SDHx<\/jats:italic>\u2010mutations in HNPGLs (<jats:italic>P<\/jats:italic> = .020), not in PCCs\/PGLs (<jats:italic>P<\/jats:italic> = .319). However, 25% of <jats:italic>SDHx<\/jats:italic>\u2010HNPGLs lacked HIF\u20101\u03b1 positive cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As in PCCs\/PGLs, SDHB immunohistochemistry in HNPGLs is a valuable method for identification of candidates for S<jats:italic>DHx<\/jats:italic>\u2010genetic testing. On the contrary, although <jats:italic>SDHx<\/jats:italic> mutations may favor HIF\u20101\u03b1 stabilization in HNPGLs, this is not a clinically useful biomarker.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25386","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T11:11:39Z","timestamp":1544785899000},"page":"79-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1\u03b1 expression in parasympathetic versus sympathetic paragangliomas"],"prefix":"10.1002","volume":"41","author":[{"given":"Crist\u00f3bal","family":"Bernardo\u2010Casti\u00f1eira","sequence":"first","affiliation":[{"name":"Institute of Sanitary Research of Asturias, Institute of Oncology of Asturias (IUOPA), CIBERONC, Hospital Central de Asturias Universidad de Oviedo  Oviedo 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