{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:12:13Z","timestamp":1787613133639,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alterations in the human epidermal growth factor receptor\u20102 (HER2) pathway have been identified in a subset of salivary duct carcinomas. Dual HER2 inhibition with trastuzumab and pertuzumab has superior antitumor efficacy to trastuzumab monotherapy in HER2\u2010positive breast cancer, yet its efficacy in HER2\u2010positive salivary duct carcinoma is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report 2 cases of exceptional responses of HER2\u2010positive salivary duct carcinomas to dual HER2 blockade and docetaxel combination and their molecular characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 54\u2010year\u2010old man with recurrent metastatic HER2 expressing salivary duct carcinoma of the parotid gland after definitive concurrent chemoradiation achieved a complete response (CR) after 6\u2009cycles of trastuzumab, pertuzumab, and docetaxel (TPH). A 42\u2010year\u2010old woman with HER2\u2010positive salivary duct carcinoma of the parotid gland with bone and liver metastases had CR with TPH and remains in remission on maintenance trastuzumab and pertuzumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dual HER2 blockage resulted in CR in patients with HER expressing salivary duct carcinoma and warrants further evaluation in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25392","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T06:55:20Z","timestamp":1543301720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Exceptional responses to pertuzumab, trastuzumab, and docetaxel in human epidermal growth factor receptor\u20102 high expressing salivary duct carcinomas"],"prefix":"10.1002","volume":"40","author":[{"given":"Jong Chul","family":"Park","sequence":"first","affiliation":[{"name":"Department of Medicine Harvard Medical School and Massachusetts General Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0053-7874","authenticated-orcid":false,"given":"T. Martin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Oncology The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Rooper","sequence":"additional","affiliation":[{"name":"Department of Pathology The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Hembrough","sequence":"additional","affiliation":[{"name":"NantOmics  Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Foss","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0571-3531","authenticated-orcid":false,"given":"Nicole C.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Sawhney","sequence":"additional","affiliation":[{"name":"Bayhealth Cancer Institute  Dover Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Flanders","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Naval Medical Center  Portsmouth Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5758-8202","authenticated-orcid":false,"given":"Hyunseok","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Oncology The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23350"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-5082-2"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0637"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00097-6"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.8612"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24634"},{"key":"e_1_2_4_8_1","volume-title":"Abstract for 9th international conference on head and neck cancer","author":"Takahashi H","year":"2016"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.06.023"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.6086"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24332"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815607449"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21116"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.6.951"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2568"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.09.008"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61121-X"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0369"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2013.03.002"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20714"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413513"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70336-9"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23429"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.9984"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2015.09.002"},{"issue":"1","key":"e_1_2_4_26_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/annonc\/mdw442","article-title":"Quantitative proteomic analysis of HER2 expression in the selection of gastric cancer patients for trastuzumab treatment","volume":"28","author":"An E","year":"2017","journal-title":"Ann Oncol"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1824"}],"container-title":["Head &amp; 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