{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:07:18Z","timestamp":1788829638850,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["217\/SGR 2081"],"award-info":[{"award-number":["217\/SGR 2081"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/02047"],"award-info":[{"award-number":["PI15\/02047"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Indications of transoral laser microsurgery (TLM) are conditioned by the risk of local relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate prognostic factors of local relapse and local control with TLM (LC\u2010TLM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Local relapse and LC\u2010TLM were evaluated in 1119 patients. Logistic regression and CHAID decision tree analysis were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Local relapse correlated to previous radiotherapy failure (8.45, CI 95%: 2.64\u201027.03; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), paraglottic involvement (2.42, CI: 1.41\u20104.15; <jats:italic>P<\/jats:italic>\u2009=\u2009.001), anterior commissure involvement (2.12, CI: 1.43\u20103.14; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), grade of differentiation (1.74, CI: 1.18\u20102.57; <jats:italic>P<\/jats:italic>\u2009=\u2009.005), and alcohol consumption (1.4, CI: 0.99\u20101.98; <jats:italic>P<\/jats:italic>\u2009=\u2009.057). Local relapse tended to inversely correlate with experience (0.73, CI: 0.51\u20101.03; <jats:italic>P<\/jats:italic>\u2009=\u2009.078). The most important factors for local relapse were previous radiotherapy failure and anterior commissure involvement.<\/jats:p><jats:p>LC\u2010TLM inversely correlated with previous radiotherapy failure (0.09, CI: 0.03\u20100.28; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), paraglottic involvement (0.25, CI: 0.14\u20100.43; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), anterior commissure involvement (0.49, CI: 0.32\u20100.77; <jats:italic>P<\/jats:italic>\u2009=\u2009.007), margins (0.56, CI: 0.30\u20101.04; <jats:italic>P<\/jats:italic>\u2009=\u2009.068), and differentiation (0.68, CI: 0.44\u20101.05; <jats:italic>P<\/jats:italic>\u2009=\u2009.087). LC\u2010TLM correlated with experience (1.71, CI: 1.13\u20102.55; <jats:italic>P<\/jats:italic>\u2009=\u2009.010). The most important factors for LC\u2010TLM were previous radiotherapy failure and paraglottic involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Previous radiotherapy failure is the most important factor for local relapse and LC\u2010TLM. In primary treatments, anterior commissure involvement and paraglottic involvement are the most important factors for local relapse and LC\u2010TLM, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25422","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T21:25:18Z","timestamp":1544131518000},"page":"756-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Factors of local recurrence and organ preservation with transoral laser microsurgery in laryngeal carcinomas; CHAID decision\u2010tree analysis"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4399-5522","authenticated-orcid":false,"given":"Isabel","family":"Vilaseca","sequence":"first","affiliation":[{"name":"Otolaryngology Department Hospital Cl\u00ednic  Barcelona Spain"},{"name":"Head Neck Cl\u00ednic Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca  Barcelona 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