{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:27:53Z","timestamp":1775021273022,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>For locally recurrent head and neck cancer, re\u2010irradiation with modern techniques like stereotactic body radiotherapy is a promising, possibly curative alternative to palliative systemic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report on 1 patient with nasopharyngeal carcinoma (NPC) and 1 patient with cutaneous squamous cell carcinoma (SCC). Both patients received full dose primary treatment (&gt;66\u2009Gy, EQD2), full dose re\u2010irradiation (&gt;50\u2009Gy, EQD2), and a second course of re\u2010irradiation via robotic radiosurgery (CyberKnife) for a second local recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both treatments resulted in adequate tumor response. No grade III\u2010IV acute or late toxicities occurred. Follow\u2010up at 6 months after third irradiation showed partial remission for the patient with NPC. In the second case (SCC), no toxicities occurred and the tumor was in remission 18\u2009months after last treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These cases show that a second course of re\u2010irradiation utilizing modern techniques like robotic radiosurgery might be feasible for carefully selected patients with head and neck cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25428","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T20:54:00Z","timestamp":1544129640000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Second infield re\u2010irradiation with a resulting cumulative equivalent dose (EQD2<sub>max<\/sub>) of &gt;180\u2009Gy for patients with recurrent head and neck cancer"],"prefix":"10.1002","volume":"41","author":[{"given":"Jens","family":"von der Gr\u00fcn","sequence":"first","affiliation":[{"name":"Department of 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