{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T15:16:54Z","timestamp":1775315814507,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T00:00:00Z","timestamp":1544832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kaposi's sarcoma (KS) is the most prevalent malignant neoplasia in human immunodeficiency virus positive (HIV+) patients for which the primary mode of management was chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We have presented the case of a newly diagnosed HIV+ male patient who was diagnosed with a pedunculated nodule in the anterior region of the hard palate, measuring 3.5 cm in diameter and with 2 months of evolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Histopathological examination confirmed the clinical hypothesis of KS. Soon after the diagnosis, the patient started using combined antiretroviral therapy (Biovir and Kaletra), presenting a significant reduction of the lesion after 4 weeks. With 1.5 cm in diameter, the lesion was surgically removed. The patient was followed\u2010up for 10 years without any recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In antiretroviral\u2010naive patients with a well\u2010preserved immune system, the use of cART may be efficient in reducing the progression of the KS lesions, thus avoiding the use of chemotherapeutic agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.25446","type":"journal-article","created":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T10:54:38Z","timestamp":1544871278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Regression of human immunodeficiency virus\u2010associated oral Kaposi sarcoma with combined antiretroviral therapy: A case report and literature review"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-4062","authenticated-orcid":false,"given":"Juliana Bertoldi","family":"Franco","sequence":"first","affiliation":[{"name":"Oral Pathology, Department of Stomatology University of Sao Paulo School of Dentistry Sao Paulo Brazil"},{"name":"Division of Dentistry Hospital of Clinics of the University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loreto Jos\u00e9","family":"Maureira Pena","sequence":"additional","affiliation":[{"name":"Special Care Dentistry Centre, Department of Stomatology University of Sao Paulo School of Dentistry Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Martins e Martins","sequence":"additional","affiliation":[{"name":"Special Care Dentistry Centre, Department of Stomatology University of Sao Paulo School of Dentistry Sao Paulo Brazil"},{"name":"School of Dentistry Santo Amaro University S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio Augusto","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Special Care Dentistry Centre, Department of Stomatology University of Sao Paulo School of Dentistry Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9573-2858","authenticated-orcid":false,"given":"Karem L.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Oral Pathology, Department of Stomatology University of Sao Paulo School of Dentistry Sao Paulo Brazil"},{"name":"Special Care Dentistry Centre, Department of Stomatology University of Sao Paulo School of Dentistry Sao Paulo 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