{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:32:08Z","timestamp":1774686728422,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most criteria require a parathyroid hormone (PTH) decline of \u226550% within 10 minutes after excision of the gland during surgery for primary hyperparathyroidism. The aim was to evaluate a model allowing earlier prediction of cure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One thousand eighteen patients with primary hyperparathyroidism were included. A \u226550% decline from baseline within 10 minutes after excision intraoperatively predicted complete removal of hypersecreting tissue. The data were reanalyzed regarding a criterion, requiring a \u226550% decline after 5 minutes. Based on the data and the present literature, an algorithm was created.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Assay predicted cure in 854 patients (true\u2010positive; 83.89%) after 10 minutes (false\u2010positive [FP] in 13 patients; 1.52%). Nevertheless, only 14 (1.83%) showed persisting disease. According to the \u201c5 minutes\u201d criterion, 723 patients (71.02%) showed a\u2009\u226550% decline from baseline within 5 minutes and 10 (1.38%) patients had a FP decline (sensitivity 0.75, specificity 0.86).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using a modified criterion, surgery can be discontinued 5 minutes earlier in 71%.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25453","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T07:49:33Z","timestamp":1543304973000},"page":"2664-2669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluating a shortened interpretation criterion for intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism: 5\u2010minutes criterion in primary hyperparathyroidism and intraoperative algorithm"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1472-6606","authenticated-orcid":false,"given":"Philipp","family":"Riss","sequence":"first","affiliation":[{"name":"Section of Endocrine Surgery, Division of General Surgery, Department of Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Dunkler","sequence":"additional","affiliation":[{"name":"Section for Clinical Biometrics, Center for Medical Statistics, Informatics, and Intelligent Systems (CeMSIIS) Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Selberherr","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Division of General Surgery, Department of Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Brammen","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Division of General Surgery, Department of Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Heidtmann","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Division of General Surgery, Department of Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Scheuba","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Division of General Surgery, Department of Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-009-0505-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80101-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7708-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.05.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00104-009-1885-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181dd4ee1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4283-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-006-0125-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.136.8.945"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181d3d264"},{"issue":"3","key":"e_1_2_7_12_1","first-page":"CR111","article-title":"Stricter criteria increase the validity of a quick intraoperative parathyroid hormone assay in primary hyperparathyroidism","volume":"15","author":"Lupoli GA","year":"2009","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4201-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5617-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4006-x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2329-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-013-1097-y"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-009-0495-7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3190-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2327-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.08.018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2016.0201"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215115000651"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0773-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.06.060"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.25453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.25453","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T23:20:05Z","timestamp":1694388005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,26]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/hed.25453"],"URL":"https:\/\/doi.org\/10.1002\/hed.25453","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,26]]},"assertion":[{"value":"2018-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}