{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:42:31Z","timestamp":1760985751404},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Castle Biosciences, Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We report the performance of a gene expression profile test to classify the recurrence risk of cutaneous melanoma tumors of the head and neck as low\u2010risk Class 1 or high\u2010risk Class 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of note, 157 primary head and neck cutaneous melanoma tumors were identified. Survival analyses were performed using Kaplan\u2010Meier and Cox methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gene expression profile class and node status stratified tumors into significantly different 5\u2010year survival groups by Kaplan\u2010Meier method (<jats:italic>P<\/jats:italic> &lt;\u2009.0001 for all end points), and both were independent predictors of recurrence in multivariate analysis. Overall, 74% of distant metastases and 88% of melanoma\u2010specific deaths had Class 2 risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The gene expression profile test identifies cases at increased risk for metastasis and death independent of a clinically or pathologically negative nodal status, suggesting that incorporation of this molecular tool could improve clinical management of patients with head and neck cutaneous melanoma, especially in those with a negative sentinel lymph node biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25473","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T20:46:26Z","timestamp":1548794786000},"page":"871-879","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Performance of a 31\u2010gene expression profile test in cutaneous melanomas of the head and neck"],"prefix":"10.1002","volume":"41","author":[{"given":"Brian R.","family":"Gastman","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Cleveland Clinic Lerner Research Institute  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan S.","family":"Zager","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology H. Lee Moffitt Cancer Center  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane L.","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology H. Lee Moffitt Cancer Center  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Cook","sequence":"additional","affiliation":[{"name":"Research &amp; Development Castle Biosciences, Inc.  Friendswood Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle R.","family":"Covington","sequence":"additional","affiliation":[{"name":"Research &amp; Development Castle Biosciences, Inc.  Friendswood Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Middlebrook","sequence":"additional","affiliation":[{"name":"Research &amp; Development Castle Biosciences, Inc.  Friendswood Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedram","family":"Gerami","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine  Chicago Illinois"},{"name":"Department of Pathology Northwestern University Feinberg School of Medicine  Chicago Illinois"},{"name":"Skin Cancer Institute Northwestern University, Lurie Comprehensive Cancer Center  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Wayne","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine  Chicago Illinois"},{"name":"Department of Surgical Oncology Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sancy","family":"Leachman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Knight Cancer Institute, Oregon Health &amp; Science University  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Vetto","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Knight Cancer Institute, Oregon Health &amp; Science University  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"issue":"9","key":"e_1_2_7_3_1","first-page":"41S","article-title":"The sunbelt melanoma trial","volume":"8","author":"McMasters KM","year":"2001","journal-title":"Ann Surg Oncol."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060992"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-004-0010-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0051"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310460"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21390"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4912-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181855718"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20875"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-2977-7"},{"issue":"3","key":"e_1_2_7_13_1","first-page":"115","article-title":"Sentinel lymph node biopsy in head and neck melanoma: a single institution analysis","volume":"135","author":"Penicaud M","year":"2014","journal-title":"Rev Laryngol Otol Rhinol (Bord)."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24094"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)80330-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.12.1472"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5590-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3316"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4016-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.051"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.34.15_suppl.9581"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9066-0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0858-x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.1335"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.1.61"},{"issue":"5","key":"e_1_2_7_27_1","first-page":"149","article-title":"Sentinel lymph node biopsy in head and neck melanoma*","volume":"35","author":"Giudice G","year":"2014","journal-title":"G Chir."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008980919928"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00837.x"},{"issue":"1","key":"e_1_2_7_30_1","first-page":"139","article-title":"The oncogenic B\u2010raf V599E mutation occurs more frequently in melanomas at sun\u2010protected body sites","volume":"29","author":"Deichmann M","year":"2006","journal-title":"Int J Oncol."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0475"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.01.007"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.02.1229"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000344"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.33.15_suppl.9074"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.4059"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24522"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4610"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613210"}],"container-title":["Head &amp; 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