{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:41:37Z","timestamp":1789872097990,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Virolab S de RL de CV"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent respiratory papillomatosis (RRP) or laryngeal papillomatosis is a disease caused by papillomavirus infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this phase I\/II clinical trial, we evaluated the efficacy of the modified vaccinia Ankara (MVA) E2 virus in the treatment of RRP. Twenty\u2010nine patients (18 female and 11 male) underwent injection of MVA E2 directly into the borders of the vocal cords where lesions were seen and were monitored by direct laryngoscopy. The immune response was assessed by the determination of CD3<jats:sup>+<\/jats:sup>, CD4<jats:sup>+<\/jats:sup>, and CD8<jats:sup>+<\/jats:sup> lymphocytes counts. The presence of papillomavirus was determined by polymerase chain reaction analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lesions were completely eliminated in 13 patients (44.8%). In 16 patients (55.2%), lesions recurred between 6 and 18\u2009months after treatment; these patients received a second round of treatment with MVA E2, and they are not seen with new recurrences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The MVA E2 vaccine has excellent potential for generating complete regression of RRP lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25477","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T16:31:50Z","timestamp":1546533110000},"page":"657-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["MVA E2 therapeutic vaccine for marked reduction in likelihood of recurrence of respiratory papillomatosis"],"prefix":"10.1002","volume":"41","author":[{"given":"Olga Rodriguez","family":"Cabo Beltran","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology National Institute of Rehabilitation  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Rosales Ledezma","sequence":"additional","affiliation":[{"name":"Virolab, S de RL de CV  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.44.1.393-400.1982"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.09.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2010.02619.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2012.00284"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199805000-00005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890120044008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.9.976"},{"issue":"1","key":"e_1_2_7_9_1","first-page":"S70","article-title":"Pathologies of the larynx and trachea in childhood","volume":"93","author":"Sittel C","year":"2014","journal-title":"Laryngorhinootologie."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31816a7135"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2012.03.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200304000-00007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-5-106"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp350"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11633"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0546-z"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100506"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.07.035"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200721010-00006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/10430340460745757"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700937"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002620000125"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2014.024"},{"key":"e_1_2_7_24_1","unstructured":"National Cancer Institute. 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