{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:23:48Z","timestamp":1790972628609,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral and pharyngeal cancers (OPC) represent the seventh most common type of cancer and the seventh leading cause of deaths by cancer worldwide. Few studies have assessed the occupational exposure risks associated with OPC and in many cases the results are conflicting. The aim of this study was to determine, through a systematic review, the association of OPC and exposure to different occupational carcinogenic substances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The addressed focused question was \u201cIs there an association of occupational carcinogenic substances with OPC?\u201d PubMed, MEDLINE, EMBASE, and ISI Web of Science databases were searched between January 1995 up to and including July 2016 using the keywords \u201coral cancer,\u201d \u201cpharyngeal cancer,\u201d \u201cpharyngeal neoplasms,\u201d \u201coral neoplasms,\u201d \u201coccupational disease,\u201d \u201coccupational exposure,\u201d and \u201coccupational risk factor\u201d in various combinations. Letters to the Editor, review articles, case reports, and unpublished articles were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen original articles were included. Majority of the studies were conducted in European countries and used a case\u2010control design. The results showed a significant association between formaldehyde, wood dust, coal dust, asbestos, welding fumes, and risk of developing OPC, while marginal association was observed with metal and leather dust. No associated risk was observed for textile fibers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is some evidence to suggest associations of occupational substances with OPC, particularly in the pharynx. Future well\u2010designed studies are required to confirm or rule out with confidence the associated exposure risk of these substances.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25486","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T15:14:45Z","timestamp":1541171685000},"page":"2724-2732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Oral and pharyngeal cancer risk associated with occupational carcinogenic substances: Systematic review"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-7455","authenticated-orcid":false,"given":"Kamran Habib","family":"Awan","sequence":"first","affiliation":[{"name":"College of Dental Medicine Roseman University of Health Sciences  South Jordan Utah United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachana","family":"Hegde","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Roseman University of Health Sciences  South Jordan Utah United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val J","family":"Cheever","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Roseman University of Health Sciences  South Jordan Utah United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Carroll","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Roseman University of Health Sciences  South Jordan Utah United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrukh","family":"Khan","sequence":"additional","affiliation":[{"name":"Centre for Rural Health College of Health and Medicine, University of Tasmania  Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankargouda","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Warnakulasuriya","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine King's College London and WHO Collaborating Centre for Oral Cancer  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5005\/jp-journals-10015-1414","article-title":"Cancer virus: the story of human papillomavirus","volume":"2","author":"Awan KH","year":"2017","journal-title":"World J Dent"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"e_1_2_8_5_1","unstructured":"International Agency on Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Betel\u2010Quid and Areca\u2010Nut Chewing and Some Areca\u2010Nut Related Nitrosamines Vol. 85 (IARC 2004)."},{"key":"e_1_2_8_6_1","unstructured":"International Agency on Research for Cancer. Smokeless Tobacco and Some Tobacco\u2010Specific N\u2010Nitrosamines. Vol. 89 (IARC 2007)."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.22452\/adum.vol18no1.3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1922"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-011-0683-y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e31823c1343"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.55.6.393"},{"key":"e_1_2_8_13_1","first-page":"317","article-title":"Occupational exposures as risk factors for oral cancer evaluated in a Swedish case\u2010control study","volume":"6","author":"Schildt EB","year":"1999","journal-title":"Oncol Rep"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.57.11.767"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(200006)37:6<581::AID-AJIM2>3.0.CO;2-D"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.6.991"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.57.6.376"},{"key":"e_1_2_8_18_1","first-page":"1145","article-title":"Occupational exposure to wood, formaldehyde, and solvents and risk of nasopharyngeal carcinoma","volume":"10","author":"Hildesheim A","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000083034.56116.0f"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdp.2006.02.001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.155"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2013-101528"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3434"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133128"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqv102"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2009.03.009"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.1706"},{"key":"e_1_2_8_28_1","unstructured":"International Agency for Research on Cancer. Occupational Exposures in Paint Manufacture and Painting. IARC mongr eval carcinog Risk Humans (IARC 1989)."},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7542"},{"key":"e_1_2_8_30_1","unstructured":"International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans. Asbestos (chrysotile amosite crocidolite tremolite actinolyte and anthophylite) 219\u2010309 (IARC 2012)."},{"key":"e_1_2_8_31_1","unstructured":"International Agency for Research on Cancer.KaneAB Boffetta P Saracci R WilbournJDeds. Mechanisms of Fibre Carcinogenesis.http:\/\/monographs.iarc.fr\/ENG\/Publications\/index2.php(WHO 1996)."},{"key":"e_1_2_8_32_1","first-page":"19","article-title":"Occupational exposure to dust and sinonasal cancer. An analysis of 386 cases reported to the N.C.C.S.F. Cancer Registry","volume":"50","author":"Van den Oever R","year":"1996","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947108000512"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700240511"},{"key":"e_1_2_8_35_1","first-page":"143","article-title":"Chemical exposures and respiratory cancer among Finnish woodworkers","volume":"50","author":"Kauppinen TP","year":"1993","journal-title":"Br J Ind Med"},{"key":"e_1_2_8_36_1","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Wood dust and formaldehyde. IARC Monogr Eval Carcinog Risks Hum (World Health Organization International Agency for Research on Cancer 1995)."},{"key":"e_1_2_8_37_1","first-page":"1","article-title":"Some metals and metallic compounds","volume":"23","author":"International Agency for Research on Cancer","year":"1980","journal-title":"IARC Monogr Eval Carcinog Risks Chem Hum"},{"key":"e_1_2_8_38_1","first-page":"1","article-title":"Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry","volume":"58","author":"International Agency for Research on Cancer","year":"1993","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_8_39_1","first-page":"1","article-title":"Cobalt in hard metals and cobalt sulfate, gallium arsenide, indium phosphide and vanadium pentoxide","volume":"86","author":"International Agency for Research on Cancer","year":"2006","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2008.10.008"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.10.018"},{"key":"e_1_2_8_42_1","unstructured":"International Agency for Research on Cancer. Chromium (VI) Compounds. A review of human carcinogens: arsenic metals fibres and dusts. 147\u2013167 (IARC 2012)."},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470301.x"},{"key":"e_1_2_8_44_1","unstructured":"International Agency for Research on Cancer. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans1980;23:205\u2010232."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11658"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2006000300009"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.25486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.25486","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T23:21:14Z","timestamp":1694388074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,2]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/hed.25486"],"URL":"https:\/\/doi.org\/10.1002\/hed.25486","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,2]]},"assertion":[{"value":"2017-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}