{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:10:07Z","timestamp":1776121807538,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Silver nanoparticles (AgNP) show efficacy in cancer cell lines. We present the first in\u2010human outcome of AgNP in a cancer patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Homemade AgNP solution is manufactured using online instructions by a 78\u2010year old male. He started consuming AgNP while on hospice after he developed nasal cavity squamous cell cancer metastatic to liver and lung.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Electron microscopy of AgNP solution revealed bimodal nanoparticle size distribution: 3 and 12\u2009nm. Inductively coupled plasma mass spectrometry showed basal silver ion concentrations of 32\u2009ng\/g, rising to 46\u2009ng\/g 1 hour after ingesting 60\u2009mL of AgNP solution. Urine showed no AgNP. No toxicities were observed and he had complete radiographic resolution of his cancer. He remains without evidence of cancer 18\u2009months later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AgNP ingestion was associated with sustained radiographic resolution of cancer. Further testing of AgNP should be done to confirm its efficacy in head and neck cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25492","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T13:47:12Z","timestamp":1544536032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-8527","authenticated-orcid":false,"given":"Jasmine","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine UT Southwestern Medical Center  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Radiology UT Southwestern Medical Center  Dallas Texas"},{"name":"UT Southwestern Harold C. Simmons Comprehensive Cancer Center, Department of Pathology  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farjana","family":"Fattah","sequence":"additional","affiliation":[{"name":"UT Southwestern Harold C. Simmons Comprehensive Cancer Center, Department of Pathology  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingya","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Texas at Dallas  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Texas at Dallas  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Kurian","sequence":"additional","affiliation":[{"name":"UT Southwestern Harold C. Simmons Comprehensive Cancer Center, Department of Pathology  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad S.","family":"Beg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine UT Southwestern Medical Center  Dallas Texas"},{"name":"UT Southwestern Harold C. Simmons Comprehensive Cancer Center, Department of Pathology  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3440-9774","authenticated-orcid":false,"given":"Saad A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine UT Southwestern Medical Center  Dallas Texas"},{"name":"UT Southwestern Harold C. 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